Antigenic polypeptide sequence of factor viii, fragments and/or epitopes there of
AssigneeCroix-Rouge de Belgique
InventorsRUTH LAUB, MARIO DI GIAMBATTISTA
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Abstract
The present invention relates to an antigenic polypeptide sequence of factor VIII, comprised between the Glutamic Acid 1649 and Asparagine 2019, preferably comprised between Arginine 1652 and Arginine 1917 of the polypeptide sequence of factor VIII, or comprised between Alanine 108 and Methionine 355, or comprised between Aspartic Acid 403 and Aspartic Acid 725, or comprised between Lysine 2085 and Lysine 2249.
Claims30
Antigenic polypeptide sequence, characterized in that it is the polypeptide sequence of factor VIII.
Antigenic polypeptide sequence, characterized in that it lacks the following fragments;
- alanine 322-serine 750, leucine 1655-arginine 1689, lysine 1694-proline 1782 and aspartic acid 2170-tyrosine 2332.
Complex comprising a carrier protein or a carrier peptide linked to an element which is selected from the group consisting of the sequence, the fragment, the epitope and/or the major part of an epitope or of a fragment according to any one of the preceding claims.
Inhibitor of factor VIII, characterized in that it exhibits an immunoaffinity with the sequence, the fragment, the epitope, the major part of an epitope or of a fragment and/or the complex according to any one of the preceding claims.
Pharmaceutical composition, characterized in that it comprises at least one element which is selected from the group consisting of the sequence, the fragment, the epitope, the major part, the complex, the inhibitor and/or the anti-inhibitor according to any one of the preceding claims.
Dependencies are inferred from the claim text.