Adjuvant formulation comprising a submicron oil droplet emulson
OwnerGary Van Nest, Gary Ott +1inventors
InventorsGary Van Nest, Gary Ott, Gail Barchfeld
Life of this patent
Estimating the term…
Abstract
An adjuvant composition, comprising a metabolizable oil and an emulsifying agent, wherein the oil and the detergent are present in the form of an oil-in-water emulsion having oil droplets substantially all of which are less than 1 micron in diameter. In preferred embodiments, the emulsifying agent is also an immunostimulating agent, such as a lipophilic muramyl peptide. Alternatively, an immunostimulating agent separate from the emulsifying agent can be used.
Claims35
An adjuvant composition, comprising:
- (1) a metabolizable oil and
- (2) an emulsifying agent, wherein said oil and said emulsifying agent are present in the form of an oil-in-water emulsion having oil droplets substantially all of which are less than 1 micron in diameter and wherein said composition exists in the absence of any polyoxypropylene-polyoxyethylene block copolymer.
The composition of claim 20, wherein said emulsifying agent comprises a polyoxyethylene sorbitan mono-, di-, or triester or a sorbitan mono-, di-, or triether.
A method of stimulating an immune response in a host animal, comprising:
- administering a protective antigen to said animal in the presence of an immunostimulating amount of submicron metabolizable oil droplets in a continuous aqueous phase and in the absence of any polyoxypropylene-polyoxyethylene block copolymer.
Dependencies are inferred from the claim text.