US 2003/0147893 A1 · Novel human transmembrane 4 superfamily protein

Abstract

The present invention provides a novel human integral membrane (TMP-1) and polynucleotides which identify and encode TMP-1. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding TMP-1 and a method for producing TMP-1. The invention also provides for agonists, antibodies, or antagonists specifically binding TMP-1, and their use, in the prevention and treatment of diseases associated with expression of TMP-1. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding TMP-1 for the treatment of diseases associated with the expression of TMP-1. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding TMP-1.

Claims57

Dependent claims

An isolated polypeptide selected from the group consisting of:

a) a polypeptide comprising the amino acid sequence of SEQ ID NO:
1,
b) a polypeptide comprising a naturally occurring amino acid sequence at least 90% identical to the amino acid sequence of SEQ ID NO:
1,
c) a biologically active fragment of a polypeptide having the amino acid sequence of SEQ ID NO:
1, and
d) an immunogenic fragment of a polypeptide having the amino acid sequence of SEQ ID NO:
1.

5 more elements

Dependencies are inferred from the claim text.

Novel human transmembrane 4 superfamily protein

Life of this patent

Novel human transmembrane 4 superfamily protein

Life of this patent

Abstract

Claims57