Method of improving wound healing
AssigneeOmnio AB
InventorsTor Ny, Jinan Li, Sten Hellstrom, Per-Olof Eriksson
Life of this patent
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Abstract
The present invention relates to the use of plasminogen and plasmin as agents for enhancing healing of tympanic membrane perforations or other wounds, and for reducing scars or necrotic tissue forming during wound healing. The invention also relates to a method for screening of compounds which enhance wound healing by evaluating the healing of tympanic membrane perforations in an animal model.
Claims33
A method of promoting healing of a tympanic membrane perforation, which comprises administering to a subject in need of such treatment a composition containing an effective amount of plasminogen for promoting healing of the tympanic membrane perforation.
A method of reducing scar formation from a healing wound, which comprises administering to a subject in need of such treatment a composition containing an effective amount of plasminogen for reducing scar formation.
A method of accelerating wound healing, which comprises administering to a subject in need of such treatment a composition containing an effective amount of plasminogen to promote healing of the wound.
A method of accelerating wound healing, which comprises administering to a subject in need of such treatment a composition containing an effective amount of plasmin to promote healing of the wound.
A method of reducing necrotic tissue formation in a healing wound, which comprises administering to a subject in need of such treatment a composition containing an effective amount of plasminogen for reducing necrotic tissue formation.
A method of identifying an agent that is useful in promoting wound healing, which method comprises:
- (i) administering a test agent to an animal having a tympanic membrane perforation;
- (ii) evaluating at least one of the extent of healing, necrotic tissue formation, and scar formation of the tympanic membrane perforation;
- (v) comparing the extent of healing, necrotic tissue formation, or scar formation to a control value;
- and
- (vi) selecting any test agent for which the extent of healing is higher or the necrotic tissue or scar formation lower than the control value as an agent useful in promoting wound healing.
Dependencies are inferred from the claim text.