Sulfatases and methods of use thereof
OwnerSteven Rosen, Stefan Hemmerich +1inventors
InventorsSteven Rosen, Stefan Hemmerich, Megumi Tomita
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Abstract
Novel sulfatases and polypeptides related thereto, as well as nucleic acid compositions encoding the same, are provided. The subject polypeptides and nucleic acid compositions find use in a variety of applications, including various diagnostic and therapeutic agent screening applications. Also provided are methods of inhibiting tumor-induced angiogenesis and methods of treating disease conditions associated therewith, particularly by administering an inhibitor of a subject sulfatase.
Claims22
An isolated polypeptide having glucosamine-6-sulfatase activity.
An isolated polynucleotide comprising a nucleotide sequence encoding a sulfatase having glucosamine-6-sulfatasc activity.
A monoclonal antibody binding specifically to a sulfatase.
A method of reducing tumor-induced angiogenesis in an individual having a tumor, the method comprising:
- administering to the individual an effective amount of an agent that inhibits enzymatic activity of a sulfatase that releases an angiogenic factor from its association with extracellular matrix, thereby reducing angiogenesis.
Dependencies are inferred from the claim text.