Method and compositions for inhibiting angiogenesis and treating cancer with IL-12 and IL-18
AssigneeThe Trustees of the University of Pennsylvania
InventorsGiorgio Trinchieri, William M.F. Lee, Christina M. Coughlin
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Abstract
A composition useful for preventing, or retarding the growth of, tumor cells contains synergistic amounts of Interleukin-12 and Interleukin-18. Similarly, methods for treating or preventing cancer include co-administering synergistic amounts of IL-12 and IL-18. The resulting anti-tumor effect is greater than the additive effect of either cytokine administered alone.
Claims22
A method for treating a mammal having a tumor by adaptive immunotherapy comprising co-administering to a mammal an engineered mammalian cell that expresses IL-12 in vivo and an engineered mammalian cell that expresses IL-18 in vivo, wherein said co-expression of said IL-12 and IL-18 induces a systemic and synergistic anti-tumor response.
14 A pharmaceutical composition for adaptive immunotherapy comprising a pharmaceutically acceptable carrier and at least one of the group consisting of an engineered mammalian cell that expresses and secretes IL-12 in vivo, an engineered mammalian cell that expresses and secretes IL-18 in vivo and an engineered mammalian cell that expresses and secretes IL-12 and IL-18 in vivo.
The composition according to claim 14, wherein said engineered cell comprises at least one regulatory sequence that directs expression of said IL-12, said IL-18, or a combination thereof.
The composition according to claim 14 wherein said carrier in a biocompatible implant.
The composition according to claim 14 wherein said cell is a tumor cell.
The composition according to claim 14 comprising a first engineered mammalian cell that expresses and secretes IL-12 in vivo and a second engineered mammalian cell that expresses and secretes IL-18 in vivo.
The composition according to claim 14 comprising an engineered mammalian cell that expresses and secretes IL-12 and IL-18 in vivo
Dependencies are inferred from the claim text.