Cell therapy using immunoregulatory T-cells
OwnerBenoit Salomon, Jose Cohen +1inventors
InventorsBenoit Salomon, Jose Cohen, David Klatzmann
Life of this patent
Estimating the term…
Abstract
The present invention relates to the fields of biology, genetics and medicine. The invention discloses methods and compositions for treating various diseases using populations or compositions of immunoregulatory T cells. The invention discloses that regulatory T cells may be produced and used to control in vivo various pathological conditions, including diseases associated with abnormal T cell activity. The invention relates to the manufacture of such regulatory T cell compositions as well as to their uses for cell therapy treatment. The invention is particularly suited for controlling graft versus host disease in subjects undergoing transplantation (e.g., bone marrow transplantation).
Claims18
A method of treatment of an immune disease in a subject, comprising administering to a subject in need thereof an amount of immunoregulatory T cells effective at suppressing a pathological immune response.
A composition comprising genetically modified freshly isolated or ex vivo expanded human immunoregulatory T cells and a pharmaceutically acceptable medium or vehicle.
A method of producing human immunoregulatory T cells, comprising:
- a) providing a biological sample comprising lymphocytes,
- b) isolating immunoregulatory T cells from said sample,
- c) expanding the immunoregulatory T cells by activation in the presence of a stimulating agent and a cytokine, and
- d) optionally genetically modifying the immunoregulatory T cells by contacting said cells with a recombinant nucleic acid molecule.
Dependencies are inferred from the claim text.