Compositions and methods for forming and strengthening bone
OwnerJ. Alexander Marchoskyinventor
Life of this patent
Estimating the term…
Abstract
Compositions are provided which stimulate bone growth. Also provided are methods for utilizing the compositions for filling in bone defects, promoting rapid fusion of bone fractures, grafts, and bone-prostheses, and promoting strengthening of osteoporotic bones.
Claims64
A composition comprising:
- (a) one or more materials selected from the group consisting of fibroblast growth factors, vascular endothelial growth factors, endothelial cell growth factors, transforming growth factors, chitosan, bone, platelet derived endothelial growth factors, placental growth factors, angiogenin, interleukin-8, granulocyte colony-stimulating growth factor, and supernatant fluid from a culture of cells known to produce angiogenic factors;
- (b) a material comprising demineralized bone matrix, non-decalcified bone matrix, with or without hyaluronic acid;
- (c) a scaffolding material selected from the group consisting of cancellous bone, chitosan, chitosan-protein, and chitin-protein fibers;
- and
- (d) a gel material selected from the group consisting of chitosan, imidazolyl chitosan, methylpyrrolidinone chitosan, carbodiimide chitosan, glutaraldehyde chitosan, a mixture of alginate with chitosan or a chitosan derivative, alginate, hyaluronic acid, or a mixture of hyaluronic acid with chitosan or chitosan derivative.
A composition comprising:
- (a) one or more angiogenesis-stimulating materials;
- (b) one or more osteoinductive materials;
- (c) one or more scaffolding materials;
- and
- (d) one or more gel materials.
A composition comprising:
- (a) one or more angiogenesis-stimulating materials selected from the group consisting of fibroblast growth factors, vascular endothelial growth factors, endothelial cell growth factors, transforming growth factors, chitosan, bone, platelet derived endothelial growth factors, placental growth factors, angiogenin, interleukin-8, and granulocyte colony-stimulating growth factor;
- (b) an osteoinductive material comprising demineralized bone matrix, non-decalcified bone matrix, with or without hyaluronic acid;
- (c) a scaffolding material selected from the group consisting of cancellous bone, chitosan, chitosan-protein, and chitin-protein fibers;
- and
- (d) a gel material selected from the group consisting of chitosan, imidazolyl chitosan, methylpyrrolidinone chitosan, carbodiimide chitosan, glutaraldehyde chitosan, and a mixture of alginate with chitosan or a chitosan derivative.
A composition for promoting the growth and strengthening of bone comprising a mixture of a chitosan or chitosan derivative, cancellous bone, and demineralized bone matrix.
A composition for promoting the growth and strengthening of bone comprising a mixture of alginate, calcium, cancellous bone, and demineralized bone matrix.
A composition for promoting the growth and strengthening of bone comprising a mixture of chitosan or chitosan derivative, alginate, cancellous bone, and demineralized bone matrix.
A composition for promoting the growth and strengthening of bone comprising a mixture of hyaluronic acid, cancellous bone, and demineralized bone matrix.
A method of filling a bone defect comprising filling the bone defect with a rigid material consisting essentially of chitin or chitosan.
Dependencies are inferred from the claim text.