Murine interferon-alpha
AssigneeZymoGenetics, Inc.
InventorsScott R. Presnell, Andrew L. Feldhaus, Zeren Gao
Life of this patent
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Abstract
Interferons represent an important class of biopharmaceutical products, which have a proven track record in the treatment of a variety of medical conditions, including the treatment of certain autoimmune diseases, the treatment of particular cancers, and the enhancement of the immune response against infectious agents. The present invention provides a new form of murine interferon-α, which has applications in diagnosis and therapy.
Claims24
An isolated polypeptide comprising a first amino acid sequence consisting of amino acid residues 22 to 199 of SEQ ID NO:2.
An isolated polypeptide comprising an amino acid sequence that is at least 70% identical to either amino acid residues 22 to 199 of SEQ ID NO:2 or amino acid residues 1 to 199 of SEQ ID NO:2, wherein the isolated polypeptide either (a) specifically binds with an antibody that specifically binds with a polypeptide consisting of the amino acid sequence of SEQ ID NO:2, or (b) exhibits anti-viral activity or anti-proliferative activity.
An isolated nucleic acid molecule that encodes an interferon polypeptide, wherein the nucleic acid molecule is either (a) a nucleic acid molecule comprising the nucleotide sequence of SEQ ID NO:3, or (b) a nucleic acid molecule that remains hybridized following stringent wash conditions to a nucleic acid molecule consisting of the nucleotide sequence of nucleotides 86 to 619 of SEQ ID NO:1, or the complement of the nucleotide sequence of nucleotides 86 to 619 of SEQ ID NO:1.
A method of inhibiting a viral infection of cells, comprising the step of administering to the cells a composition comprising an isolated polypeptide comprising an amino acid sequence of amino acid residues 22 to 199 of SEQ ID NO:2.
A method of inhibiting the proliferation of tumor cells, comprising the step of administering to the cells a composition comprising an isolated polypeptide comprising an amino acid sequence of amino acid residues 22 to 199 of SEQ ID NO:2.
Dependencies are inferred from the claim text.