Methods of using macrophage inflammatory protein-4 (MIP-4) and myeloid progenitor inhibitory factor-1 (MPIF-1) polypeptides
AssigneeHuman Genome Sciences, Inc.
InventorsSteven M. Ruben, Haodong Li
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Abstract
There are disclosed therapeutic compositions and methods using isolated nucleic acid molecules encoding a human myeloid progenitor inhibitory factor-1 (MPIF-1) polypeptide (previously termed MIP-3 and chemokine β8 (CKβ8 or ckb-8)); a human monocyte-colony inhibitory factor (M-CIF) polypeptide (previously termed MIP1-γ and chemokine β1 (CKβ1 or ckb-1)), and a macrophage inhibitory protein-4 (MIP-4), as well as MPIF-1, M-CIF and/or MIP-4 polypeptides themselves, as are vectors, host cells and recombinant methods for producing the same.
Claims5
A method of chemoattracting leukocytes comprising administering to said leukocytes a polypeptide comprising a fragment of the polypeptide encoded by the MPIF-1 clone in ATCC Deposit No. 75676 wherein said fragment has chemoattractant activity, and wherein said fragment comprises the conserved Cys residues.
A method of chemoattracting leukocytes comprising administering to said leukocytes a polypeptide comprising a fragment of the polypeptide encoded by the MIP-4 clone in ATCC Deposit No. 75675 wherein said fragment has chemoattractant activity, and wherein said fragment comprises the conserved Cys residues.
Dependencies are inferred from the claim text.