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US 2003/0147814 A1Published application
Medicinal aerosol formulations comprising ion pair complexes
Assignee3M Innovative Properties Company
InventorsRobert A. Scherrer, James S. Stefely, Stephen W. Stein
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Abstract
The invention comprises hydrofluorocarbon medicinal aerosol solutions comprising an ion pair complex comprising a drug and an excipient. The invention also relates to methods for delivering a highly respirable dose to a mammal with a medicinal aerosol comprising an ion pair complex.
Claims20
A medicinal aerosol formulation comprising:
- a hydrofluorocarbon propellant;
- an ion pair complex comprising a drug and an excipient, wherein the excipient is a compound of the structure R1—X;
- wherein R1 is a linear, branched, or cyclic hydrocarbon with 1 to 26 carbons, which may be optionally interrupted by a —O—, —S—, or —N(R4)— group;
- X is selected from the group consisting of:
- —C(O)OH;
- —S(O2)OH;
- —OS(O2)OH;
- —OP(OH)2O;
- —P(OH)2O and —N(R4)(R4);
- and
- R4 is hydrogen or a linear, branched, or cyclic hydrocarbon with 1 to 18 carbons;
- and further wherein the propellant and ion pair complex form a solution.
9 more elements
A method of delivering a medicinal aerosol to a mammal comprising:
- providing a drug with a solubility in propellant alone of less than 0.5% by weight;
- preparing a medicinal solution comprising a mixture of a hydrofluorocarbon propellant and an ion pair complex comprising the drug and an excipient;
- preparing a metered dose inhaler comprising the medicinal solution, a canister, and an actuator;
- placing the metered dose inhaler in fluid communication with the oral cavity of a mammal;
- and
- delivering a respirable dose of drug greater than 30 micrograms to the mammal with a single actuation of the metered dose inhaler.
3 more elements
A medicinal aerosol solution formulation product comprising:
- an aerosol container equipped with a dispensing valve;
- an actuator;
- and
- a medicinal aerosol formulation contained within the aerosol container;
- wherein the medicinal aerosol formulation comprises:
- a hydrofluorocarbon propellant;
- an ion pair complex comprising a drug and an excipient;
- wherein the drug has a solubility in propellant alone of less than 0.5% by weight, and further wherein the propellant and ion pair complex form a solution;
- wherein the medicinal aerosol solution formulation product will deliver a respirable dose of drug greater than 30 micrograms when actuated.
6 more elements
Dependencies are inferred from the claim text.