Antibodies against the MUC18 antigen
AssigneeAbgenix, Inc.
InventorJean Gudas
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Abstract
The present invention relates generally to the generation and characterization of anti-MUC18 monoclonal antibodies. The invention further relates to the use of such anti-MUC18 antibodies in the diagnosis and treatment of disorders associated with increased activity of MUC18, in particular, tumors, such as melanomas.
Claims14
An isolated monoclonal antibody comprising a heavy chain amino acid, wherein said amino acid has an amino acid sequence selected from the group consisting of SEQ ID NOs:
- 1, 5 9, 13, 17, 21, 25, 29, 33 and 37, and wherein said monoclonal antibody binds to MUC18.
A monoclonal antibody comprising a heavy chain variable domain encoded by a nucleic acid molecule having a nucleotide sequence selected from the group consisting of SEQ ID NOs:
- 3, 7, 11, 15, 19, 23, 27, 31, 35 and 39.
Dependencies are inferred from the claim text.