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OwnerKai-Uwe Zirk, Harald Potzschkeinventors
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The invention relates to a method for the long-term stable and well-reproducible spectrometric measurement of the concentrations of components of aqueous solutions, especially of dialysates of interstitial tissue fluids, especially the glucose concentration. The inventive method comprises splitting a measuring beam into two partial beams by means of a beam splitter (2), and guiding one partial beam through a measuring cuvette (3), that is separated from the solution to be measured for example by a diaphragm, or that is connected to a pump system with an exchange path that is separated from the solution to be measured by a diaphragm. The other partial beam is guided through a reference cuvette (4) that is filled with a reference solution. The light intensity of both partial beams is measured and the measured signals are subjected to a symmetrical signal processing, optionally after suitable amplification. The invention further relates to a device for carrying out the inventive method, which device can be especially miniaturized.
A method for spectrometric measurement that is stable over time and is readily reproducible, specifically the measurement of the concentrations of components of aqueous solutions, in particular the dialysates of interstitial tissue fluids, in which method a measuring beam is divided into two partial beams by a beam-splitter, one partial beam is conducted through a measuring cuvette and the other partial beam is conducted through a cuvette that is filled with a reference solution, the luminous intensities of both partial beams are measured and the measuring signals are fed, if necessary after suitable amplification, to a symmetrical signal processing component, wherein the intensity of the measuring beam fluctuates in uniformly periodic fashion over time, within the signal processing component the signal of each partial beam is first fed to a multiplier, and one multiplier performs a signal inversion, which is followed by the process of subtraction or ratio formation.
A device for spectrometric measurement that is stable over time and is readily reproducible, specifically the measurement of the concentrations of components of aqueous solutions, particularly the dialysates of interstitial tissue fluids, which device consists of a radiation source (1) with an intensity that fluctuates in uniformly periodic fashion over time, a beam-splitter (2), a measuring cuvette (3) positioned in the measuring beam portion, a reference cuvette (4) which is positioned in the reference beam portion and is filled with a quantity of the unchanged substance being analyzed, in a concentration comparable to that anticipated for the solution being measured, detectors (5 and 6) positioned in the beam paths behind the sampling and reference cuvettes, for measuring the luminous intensity of the partial beams, current-voltage transformers (7 and 8) for transforming the signals into electrical signals, a multiplier (9 and 10) for each of the two partial signals, one of which multipliers inverts the signal, and a device for processing and evaluating the signals.
Dependencies are inferred from the claim text.