Method and apparatus to pack high efficiency columns for chromatography
OwnerGeorges A. Guiochoninventor
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Abstract
Eliminating the friction between the packing material and the inner surface of a chromatographic column during the packing of the column provides a column that has a stationary phase that is substantially radially homogenous within the column. A preferred way to eliminate the friction is by vibrating the column in a direction substantially parallel to its long axis.
Claims35
A method for packing a chromatographic column comprising loading the column with a packing material and essentially eliminating the friction between the packing material and the inner wall of the chromatographic column.
A method for reducing friction between the interior surface of a chromatographic column and a bed of packing material contained within the column comprising vibrating the column in a direction substantially parallel to its length.
A packed chromatographic column in which the reduced HETP of the column is less than 2.
A packed chromatographic column containing a bed of packing material that is substantially radially homogenous.
A method for separating one or more compounds from a mixture of compounds comprising inserting the mixture into one end of a chromatographic column that has been packed while being vibrated in a direction substantially parallel to its long axis and permitting the compounds to travel along the length of the column and exit at the opposite end of the column.
An apparatus for vibrating a chromatographic column comprising a holder for the chromatographic column and a vibrator that vertically oscillates the column, wherein the holder maintains the column in a substantially vertical direction during the oscillation.
Dependencies are inferred from the claim text.