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OwnerVolker Unkrig, Michael Marquant +4inventors
InventorsVolker Unkrig, Michael Marquant, Fritz Hindelang, Holger Kotzan, Carina Horn, Christine Nortmeyer
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The invention concerns an electrochemical sensor based on dry chemistry for determining blood coagulation or individual coagulation factors which has at least two electrodes on an inert support as well as a dry reagent, characterized in that the reagent contains a protease substrate which is composed of a peptide residue that can be cleaved off by a thrombin and is bound to a phenylenediamine residue via an amide bond at its carboxyl end and a system for measuring blood coagulation containing such a sensor and an amperometer, a method for determining blood coagulation using the sensor according to the invention and a reagent for determining blood coagulation containing a thrombin substrate which is composed of a peptide residue that can be cleaved off by thrombin and is bound via its carboxyl end to a phenylenediamine residue by means of an amide linkage, characterized in that it also contains a dye-oxidoreductase such as glucose-dye-oxidoreductase.
Electrochemical sensor based on dry chemistry for determining blood coagulation or individual coagulation factors which has at least two electrodes on an inert support as well as a dry reagent, characterized in that the reagent contains a protease substrate which is composed of a peptide residue that can be cleaved off by a protease of the blood coagulation system and is bound to substituted anilines and in particular to a phenylenediamine residue via an amide bond at its carboxyl end.
Reagent for the determination of blood coagulation containing a protease substrate which is composed of a peptide residue that can be cleaved off by a protease of the blood coagulation system which is bound via its carboxyl end and an amide linkage to a phenylenediamine residue, characterized in that it contains a dye-oxidoreductase.
Dependencies are inferred from the claim text.