Agent delivery and aspiration device

28) An apparatus for the delivery of an agent into an orifice and the subsequent aspiration of the orifice contents, comprising:

• a. an agent delivery and aspirating assembly for delivering said agent and subsequently aspirating the orifice contents, the agent delivery and aspirating assembly including:
• i. a means for generating a positive pressure for delivering said agent and a negative pressure for aspiring the orifice contents;
• ii. a means for delivering said agent to a device tip assembly;
• iii. a means for applying said negative pressure to the orifice through the device tip assembly;
• iv. a means for sealably connecting said agent delivery and aspirating assembly to the device tip assembly;
• and
• b. a device tip assembly for dispensing said agent from the agent delivery assembly and aspirating the orifice contents from the orifice, said device tip assembly including:
• i. a nozzle means for dispensing said agent and aspirating the orifice contents from the orifice to a storage means;
• ii. a means for transporting the orifice contents from the device tip assembly to a storage means contained within said apparatus;
• and
• iii. a means for sealably connecting the device tip assembly to said agent delivery and aspirating assembly.

38) An apparatus for the delivery of an agent into an orifice of an individual and the subsequent aspiration of the orifice contents from the orifice of said individual, wherein said orifice contents removed from said individual are analyzed for the presence of a target, comprising:

• a. an agent delivery assembly, including:
• i. a means for generating a positive pressure for delivering said agent;
• ii. a means for delivering said agent to a device tip assembly;
• ii. a means for sealably connecting said agent delivery assembly to said device tip assembly;
• b. an aspirating assembly, including:
• i. a means for generating a negative pressure for aspirating the orifice contents from the orifice through the device tip assembly;
• ii. a storage means for the aspirated orifice contents, whereby said storage means is sealably connected and removable from said apparatus;
• iv. a means for sealably connecting said aspirating assembly to said device tip assembly;
• c. a device tip assembly, including:
• i. a nozzle means for dispensing said agent received from said delivery assembly and aspirating the orifice contents from the orifice;
• ii. a means for sealably connecting said device tip assembly to said agent delivery assembly and said aspirating assembly.

51) A method for the delivery of at least one agent into an orifice and the subsequent removal of the orifice contents, comprising:

• a. providing a positive pressure means for delivery of said agent to the orifice;
• b. delivering said agent to the orifice;
• and
• c. providing a negative pressure means for aspiration of the orifice contents to a storage means contained within the apparatus.

62) A method for the detection of a target present within an orifice, whereby an agent is delivered into the orifice and the orifice contents are subsequently aspirated from the orifice, comprising:

• a. providing a positive pressure means for delivery of said agent to the orifice;
• b. delivering said agent to the orifice;
• c. providing a negative pressure means for aspiration of the orifice contents to a storage means;
• and
• d. assaying of the orifice contents contained within said storage means;
• whereby said orifice contents are assayed for the presence of a target.