Back to results
US 2003/0145394 A1Published application
Helium-neon excitable reticulocyte dyes derivable from halolepidines
AssigneeAbbott Laboratories
InventorsNai-Yi Wang, Alex W.C. Yem
Life of this patent
Estimating the term…
Loading patent…
Loading patent…
AssigneeAbbott Laboratories
InventorsNai-Yi Wang, Alex W.C. Yem
Estimating the term…
A method for synthesizing dyes excitable by a helium-neon laser (excitable at 633 nm) from hololepidines, e.g., 7-halolepidine, which dyes are suitable for detection and enumeration of reticulocytes in human blood samples. In another aspect, the invention provides a method for immunotyping phenocytes. The method is based on the phenomenon that when dyes of certain structure intercalate into DNA or RNA, the intensity of the dye increases. Dyes suitable for this invention can be described as having (a) a first heterocyclic moiety, (b) a second heterocyclic moiety, and (c) a linking group that connects the first and second heterocyclic moieties. Both the first and second heterocyclic moieties must contain at least two rings, preferably fused together. The dye is characterized by conjugation, whereby the first moiety is ethylenically conjugated to the second moiety.
A dye having (a) a first heterocyclic moiety, (b) a second heterocyclic moiety, and (c) a linking group that connects the first and second heterocyclic moieties, said first and second heterocyclic moieties must having at least two rings, said heterocyclic moieties being characterized by conjugation whereby the first moiety is ethylenically conjugated to the second moiety.
A compound having the structure
Dependencies are inferred from the claim text.