Osteoimplant and method for making same

The method of clam 17 wherein the bone possess a total surface area of between about 100 mm2 and about 10,000 mm2.

The method of clam 17 wherein, the bone possess a total surface area of between about 250 mm2 and about 8000 mm2.

The method of clam 17 wherein, the bone possess a total surface area of between about 300 mm2 and about 7600 mm 2.

A surface demineralized osteoinductive osteoimplant comprising monolithic bone, the osteoimplant having at least one outer surface possessing at least one demineralized zone at least about 100 microns thick and a non-demineralized zone, wherein the non-demineralized zone is configured to reversibly engage with an insertion device.

A load-bearing vertebral interbody fusion device comprising a monolithic section of bone configured to span a space selected from the group consisting of an intervertebral space between adjacent vertebrae and a space between non-adjacent vertebrae, the bone having at least one outer surface with at least one demineralized zone for contacting the adjacent vertebra and a non-demineralized zone, the non-demineralized zone being configured to maintain relatively close tolerances with an insertion instrument.

A method for promoting joint fusion in an animal in need thereof, the method comprising:

• implanting in the animal an osteoinductive osteoimplant made of bone having an outer surface possessing at least one demineralized zone, the demineralized zone of the outer surface of the bone being at least about 100 microns thick, the osteoimplant having at least one non-demineralized zone provided by configuring at least a portion of the demineralized zone.

A method of treating a bone defect in an animal in need thereof, the method comprising:

• applying an osteoimplant to a defect site such that the surface of the osteoimplant conforms to the surface of the bone defect site, wherein the osteoimplant is an osteoinductive osteoimplant comprising of bone having an outer surface possessing at least one demineralized zone and at least one non-demineralized zone, the demineralized zone of the outer surface of the bone being at least about 100 microns thick, the non-demineralized zone being provided by configuring at least a portion of the demineralized zone.

A method for manufacturing a load-bearing osteoinductive osteoimplant comprising:

• demineralizing at least a portion of at least one surface of a monolithic section of cortical bone to a depth of from about 100 to about 2000 microns to provide a surface demineralized monolithic section of cortical bone;
• and,
• configuring the monolithic section of cortical bone to provide a load-bearing osteoinductive osteoimplant possessing an outer surface possessing at least one demineralized zone and a non-demineralized inner core.

A load-bearing osteoinductive osteoimplant comprising a monolithic section of bone, said bone possessing at least one outer surface possessing at least one demineralized zone and at least one non-demineralized zone, said cortical bone possessing a non-demineralized core, wherein the demineralized zone of the outer surface of the bone is from about 100 to about 2000 microns thick, the non-demineralized zone of the outer surface being provided by configuring at least a portion of the demineralized zone.

A vertebral interbody fusion device comprising a monolithic section of bone configured to span an intervertebral space selected from the group consisting of an intervertebral space between adjacent vertebrae and a space between non-adjacent vertebrae, said bone possessing at least one outer surface possessing at least one demineralized zone, said bone possessing a non-demineralized core, wherein the demineralized zone of the outer surface of the bone is from about 100 to about 2000 microns thick, the fusion device having at least one non-demineralized zone provided by configuring at least a portion of the demineralized zone.