Method and apparatus for optimizing stroke volume during DDD resynchronization therapy using adjustable atrio-ventricular delays
AssigneeCardiac Pacemakers, Inc.
InventorsYinghong Yu, Jiang Ding, Julio C. Spinelli, Andrew P. Kramer
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Abstract
A pacing system for providing optimal hemodynamic cardiac function for parameters such as ventricular synchorny or contractility (peak left ventricle pressure change during systole or LV+dp/dt), or stroke volume (aortic pulse pressure) using system for calculating atrio-ventricular delays for optimal timing of a ventricular pacing pulse. The system providing an option for near optimal pacing of multiple hemodynamic parameters. The system deriving the proper timing using electrical or mechanical events having a predictable relationship with an optimal ventricular pacing timing signal.
Claims30
A system, comprising:
- a signal input including:
- a cardiac signal input to receive at least one cardiac signal indicative of cardiac events including at least one atrial event, A;
- and
- a mechanical signal input to receive at least one pressure signal indicative of a predetermined pressure event, X;
- a measurement module, coupled to the signal input, to measure a time interval (AX) between A and X;
- and
- an atrio-ventricular delay (AVD) calculator coupled to the measurement module, the AVD calculator adapted to calculate an AVD based on the AX to provide an approximately maximum aortic pulse pressure by delivering ventricular pacing pulses with the AVD.
A method, comprising:
- delivering an atrial pacing pulse;
- detecting an predetermined pressure event;
- measuring an atrio-ventricular time interval (AX) between the delivery of the atrial pacing pulse (A) and the pressure event (X);
- calculating an atrio-ventricular delay (AVD) based on the AX to provide an approximately maximum aortic pulse pressure by delivering ventricular pacing pulses with the AVD;
- and
- delivering the ventricular pacing pulses with the AVD.
A computer-readable medium having computer-executable instructions to cause a computer or computer-based system to perform a method comprising:
- receiving a time interval (AX) between an atrial event (A) and a predetermined intracardiac pressure event (X);
- and
- calculating an atrio-ventricular delay (AVD) based on the AX to provide an approximately maximum aortic pulse pressure by delivering ventricular pacing pulses with the AVD.
23 The computer-readable medium of claim 21, wherein receiving the AX comprises receiving a time interval between an intrinsic atrial contraction and a peak of a left ventricular presystolic pressure.
Dependencies are inferred from the claim text.