Patent foramen ovale (PFO) closure method and device
AssigneeNMT Medical, Inc.
InventorsAndrzej J. Chanduszko, Steven W. Opolski, Carol A. Ryan
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Abstract
The present invention provides methods and devices for closing two overlapping layers of tissue in a mammalian heart, for example a patent foramen ovale (PFO). The closure devices may take a number of different forms and may be retrievable. In some embodiments, the closure devices may be delivered with a catheter capable of puncturing mammalian tissue.
Claims77
A method of closing septum primum and septum secundum in a mammalian heart, comprising:
- (a) inserting a closure device into a right atrium of said heart, said device including first and second ends;
- (b) puncturing septum primum and passing a portion of said closure device through septum primum into a left atrium of said heart;
- (c) puncturing septum secundum at said first end of said closure device after said closure device has passed through septum primum;
- and
- (d) positioning said second end of said closure device against septum secundum in the right atrium such that said closure device provides a compressive force to compress at least one of septum primum and septum secundum therebetween.
A device for closing two overlapping layers of septum primum and septum secundum dividing a left atrium and a right atrium in a mammalian heart, said device having first and second ends, wherein said device is sized and shaped to extend from septum secundum, into the left atrium, through septum primum, and into the right atrium, said first and second ends cooperating to provide a compressive force to the overlapping layers of tissue.
A method of closing two overlapping layers of tissue in a mammalian heart, comprising:
- (a) inserting into a right atrium of said heart a closure device including a grappling hook member joined to at least two curved arms by an enlarged-tip joinder member, said grappling hook member including at least two grappling hooks capable of being reversibly and distally elongated along a lengthwise axis;
- (b) puncturing septum primum and passing a portion of said closure device through septum primum and into a left atrium of said heart;
- (c) deploying said grappling hook member into the left atrium such that said grappling hooks are embedded into the surfaces of septum primum and septum secundum exposed in the left atrium;
- (d) drawing together septum primum and septum secundum;
- and
- (e) deploying said curved arms such that said curved arms engage the surfaces of septum primum and septum secundum exposed in the right atrium to compress septum primum and septum secundum and close the overlapping layers of tissue.
A device for closing two overlapping layers of tissue in a mammalian heart, comprising a grappling hook member joined to at least one curved arm by an enlarged-tip joinder member, wherein said grappling hook member includes at least one grappling hook capable of being reversibly and distally elongated along a lengthwise axis.
A method of closing two overlapping layers of tissue in a mammalian heart, comprising:
- (a) inserting a catheter into a right atrium of said heart, said catheter containing a closure device consisting essentially of first and second opposed grappling hook members and a central connecting member, wherein each of said grappling hook members includes at least two curved grappling hooks capable of being reversibly and distally elongated so as to lie along the longitudinal axis of said connecting member;
- (b) inserting said catheter between the overlapping layers of tissue and into a left atrium of said heart;
- (c) deploying said first grappling hook member into the left atrium;
- (d) retracting said catheter into the right atrium, such that said grappling hooks of said first grappling hook member are embedded into the surfaces of septum primum and septum secundum exposed in the left atrium and said connecting member extends at an angle between septum primum and septum secundum, thereby drawing together septum primum and septum secundum and closing said overlapping layers of tissue;
- and
- (e) further retracting said catheter out of the right atrium, such that said second grappling hook member is deployed and said grappling hooks of said second grappling hook member are embedded into the surfaces of septum primum and septum secundum exposed in the right atrium.
A method for closing two overlapping layers of tissue in a mammalian heart, comprising inserting a closure device into said heart, said closure device consisting essentially of first and second opposed grappling hook members and a central connecting member, wherein said grappling hook members, when deployed, compress septum primum and septum secundum, thereby closing said overlapping layers of tissue.
A device for closing two overlapping layers of tissue in a mammalian heart, consisting essentially of first and second opposed grappling hook members and a central connecting member, wherein each of said grappling hook members includes at least two curved grappling hooks capable of being reversibly and distally elongated so as to lie along the longitudinal axis of said connecting member.
A device for closing a patent foramen ovale (PFO) in a mammalian heart, consisting essentially of a first grappling hook member including at least two proximally-curved grappling hooks, and a central connecting member, wherein said grappling hook member is capable of being reversibly and distally elongated so as to lie along the longitudinal axis of said connecting member.
A method of closing two overlapping layers of tissue in a mammalian heart, comprising:
- (a) inserting a septal needle catheter into a right atrium of said heart, said catheter containing at least one closure device having first and second ends, wherein said first end of said closure device is a closure device anchor;
- (b) puncturing septum secundum and then septum primum with said septal needle catheter such that said catheter enters a left atrium of said heart,
- (c) deploying said first end of said closure device into the left atrium,
- (d) retracting said catheter through septum primum and then septum secundum, whereby said first end of said closure device is pulled against the surfaces of septum primum and septum secundum exposed in the left atrium;
- (e) further retracting said catheter our of the right atrium, such that said second end is deployed in the right atrium;
- and
- (f) forming said second end of said closure device into a structure having a diameter larger than that of said catheter such that said second end is maintained in the right atrium, thereby drawing septum primum and septum secundum together and closing said overlapping layers of tissue.
Dependencies are inferred from the claim text.