Compositions and methods for treating disease utilizing a combination of radioactive therapy and cell-cycle inhibitors
AssigneeAngiotech Pharmaceuticals, Inc.
InventorsWilliam L. Hunter, David M. Gravett, Richard T. Liggins, Troy A.E. Loss, Arpita Maiti, Philip M. Toleikis
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Abstract
Disclosed herein are therapeutic devices, compositions and methods for treating proliferative diseases. For example, within one aspect of the invention therapeutic devices are provided, comprising a device that locally administers radiation and a cell-cycle inhibitor
Claims38
A therapeutic device, comprising a device which locally administers radiation, and a cell-cycle inhibitor.
A therapeutic device, comprising:
- a radioactive source sized to be positioned into the tissue of a patient adjacent to a site to be treated by locally administered radiation from the radioactive source;
- and a cell-cycle inhibitor positioned adjacent to the radioactive source.
A therapeutic device, comprising:
- a radioactive source sized to be positioned into a pre-existing or created body cavity of a patient adjacent to a site to be treated by locally administered radiation from the radioactive source;
- and a cell-cycle inhibitor positioned adjacent to the radioactive source.
A therapeutic device, comprising:
- a radioactive source;
- a capsule containing the radioactive source, the capsule being sized to be positioned into a pre-existing or created body cavity of a patient adjacent to a site to be treated by locally administered radiation from the radioactive source;
- and a cell-cycle inhibitor.
A therapeutic device, comprising:
- a radioactive source;
- a body contact material carrying the radioactive source, the body contact member being applied to a pre-existing or created surface site of a patient's body to be treated by locally administered radiation from the radioactive source;
- and a cell-cycle inhibitor.
A composition, comprising a radioactive source and a cell-cycle inhibitor.
A method for treating a hyperproliferative disease of the prostate, comprising administering to the prostate a cell cycle inhibitor and a radioactive source, such that said hyperproliferative disease of the prostate is treated.
A method for treating a hyperproliferative disease of the anorectum, comprising administering to the anorectum a cell cycle inhibitor and a radioactive source, such that said hyperproliferative disease of the anorectum is treated.
A method for treating a hyperproliferative disease of the bladder or urinary tract, comprising administering to the bladder or urinary tract a cell cycle inhibitor and a radioactive source, such that said hyperproliferative disease is treated.
A method for treating a hyperproliferative disease of the eye, comprising administering to the eye a cell cycle inhibitor and a radioactive source, such that said hyperproliferative disease is treated.
A method for treating a hyperproliferative disease of the brain, comprising administering to the brain a cell cycle inhibitor and a radioactive source, such that said hyperproliferative disease is treated. 25. A method for treating a hyperproliferative disease of the breast, comprising administering to the breast a cell cycle inhibitor and a radioactive source, such that said hyperproliferative disease of the breast is treated.
A method for treating a hyperproliferative disease of the esophagus, comprising administering to the esophagus a cell cycle inhibitor and a radioactive source, such that said hyperproliferative disease is treated.
A method for treating a hyperproliferative disease of the uterus or cervix, comprising administering to the uterus or cervix a cell cycle inhibitor and a radioactive source, such that said hyperproliferative disease is treated.
A method for treating a hyperproliferative disease of the liver or bile duct, comprising administering to the liver or bile duct a cell cycle inhibitor and a radioactive source, such that said hyperproliferative disease is treated.
A method for treating a hyperproliferative disease of the lung, comprising administering to the lung a cell cycle inhibitor and a radioactive source, such that said hyperproliferative disease is treated.
A method for treating a hyperproliferative disease of the pancreas, comprising administering to the pancreas a cell cycle inhibitor and a radioactive source, such that said hyperproliferative disease is treated.
A method for treating soft-tissue sarcomas, comprising administering to a soft-tissue sarcoma a cell cycle inhibitor and a radioactive source, such that sarcoma is treated.
A method for treating a hyperproliferative disease of the skin, comprising administering to the skin a cell cycle inhibitor and a radioactive source, such that said hyperproliferative is treated.
A method for treating a hyperproliferative disease of the head or neck, comprising administering to the head or neck a cell cycle inhibitor and a radioactive source, such that said hyperproliferative disease is treated.
A radioactive polymer comprising a radioactive monomer and a non-radioactive monomer.
Dependencies are inferred from the claim text.