Process for preparing citalopram
AssigneeEsteve Quimica, S.A.
InventorsLaura Coppi, Yolanda Gasanz Guillen, Julio Campon Pardo
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Abstract
Process for preparing purified citalopram or one of its salts that comprises the purification of citalopram by selective extractions of citalopram or of its impurities with organic solvents and water under specific conditions of pH and temperature. The crude citalopram can be prepared by a process that comprises reacting 1-[3-(dimethylamine)propyl]-1-(4-fluorophenyl)-1,3-dihydro-5-bromoisobenzofuran with copper cyanide.
Claims14
A process for preparing pure citalopram that comprises purifying citalopram by selective extractions of citalopram or of its impurities with organic solvents and water.
A process for preparing pure citalopram that comprises reacting 1-[3-(dimethylamine)propyl]-1-(4-fluorophenyl)-1,3-dihydro-5-bromoisobenzofuran with copper cyanide in the absence of solvent to obtain crude citalopram and purifying the crude citalopram by selective extractions of citalopram or of its impurities with organic solvents and water.
Dependencies are inferred from the claim text.