Compositions and methods for the therapy and diagnosis of ovarian cancer
AssigneeCorixa Corporation
InventorsPaul A. Algate, Jane Mannion
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Abstract
Compositions and methods for the therapy and diagnosis of cancer, particularly ovarian cancer, are disclosed. Illustrative compositions comprise one or more ovarian tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly ovarian cancer.
Claims17
An isolated polynucleotide comprising a sequence selected from the group consisting of:
- (a) sequences provided in SEQ ID NOs:
- 1-88 and 91-94;
- (b) complements of the sequences provided in SEQ ID NOs:
- 1-88 and 91-94;
- (c) sequences consisting of at least 20 contiguous residues of a sequence provided in SEQ ID NOs:
- 1-88 and 91-94;
- (d) sequences that hybridize to a sequence provided in SEQ ID NOs:
- 1-88 and 91-94, under highly stringent conditions;
- (e) sequences having at least 75% identity to a sequence of SEQ ID NOs:
- 1-88 and 91-94;
- (f) sequences having at least 90% identity to a sequence of SEQ ID NOs:
- 1-88 and 91-94;
- and
- (g) degenerate variants of a sequence provided in SEQ ID NOs:
- 1-88 and 91-94.
An oligonucleotide that hybridizes to a sequence recited in SEQ ID NOs:
- 1-88 and 91-94 under highly stringent conditions.
Dependencies are inferred from the claim text.