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OwnerShubhada D. Godbole, Chiaoyun Kuo +6inventors
InventorsShubhada D. Godbole, Chiaoyun Kuo, Matthew C. Arterburn, George Yeung, Servando Palencia, Y. Tom Tang, Chenghua Liu, Radoje T. Drmanac
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The invention provides novel polynucleotides and polypeptides encoded by such polynucleotides and mutants or variants thereof that correspond to a novel human secreted cadherin-like polypeptide. These polynucleotides comprise nucleic acid sequences isolated cDNA library prepared from human umbilical cord mRNA (Biochain) (SEQ ID NO: 1). Other aspects of the invention include vectors containing processes for producing novel human secreted cadherin-like polypeptides, and antibodies specific for such polypeptides.
An isolated polynucleotide comprising a nucleotide sequence selected from the group consisting of SEQ ID NO:
An isolated polypeptide comprising an amino acid sequence which is at least 95% identical to the amino acid sequence selected from the group consisting of SEQ ID NO:
A polypeptide, having cadherin-like activity, comprising at least twenty consecutive amino acids from the polypeptide sequences selected from the group consisting of SEQ ID NO:
A polynucleotide encoding a polypeptide according to claim 111.
A method of treatment of a subject having need to inhibit activity or expression of cadherin-like polypeptide comprising administering to the subject a composition selected from the group consisting of:
Dependencies are inferred from the claim text.