Back to results
US 2003/0144489 A1Published application
Method for screening nucleic acid catalysts
OwnerAlex Burgin, Leonid Beigelman +2inventors
InventorsAlex Burgin, Leonid Beigelman, Laurent Bellon, Shawn Zinnen
Life of this patent
Estimating the term…
Abstract
Nucleic acid catalysts, method of screening for variants of nucleic acid catalysts, synthesis of enzymatic nucleic acid molecule libraries and discovery of gene sequences are described.
Claims21
A nucleic acid molecule with an endonuclease activity having the formula VI:
- X CNNNNN GGCGUAAGCC GU Y (SEQ ID No:
- 1)
- wherein, each n independently represents a nucleotide or a non-nucleotide, which may be same or different;
- X and Y are independently oligonucleotides of length sufficient to stably interact with a target nucleic acid molecule;
- and C, U and G represent adenosine, cytidine, uridine and guanosine nucleotides, respectively each of which can independently be chemically modified at the nucleic acid base, sugar, or backbone.
2 more elements
A nucleic acid molecule with catalytic activity having the formula VII:
- 6 X U GGCGUUAGCC NNN GGCGUUAGCC NC Y (SEQ ID No:
- 2)
- wherein, each n independently represents a nucleotide or a non-nucleotide, which may be same or different;
- X and Y are independently oligonucleotides of length sufficient to stably interact with a target nucleic acid molecule;
- and A, C, U and G represent adenosine, cytidine, uridine and guanosine nucleotides, respectively each of which can independently be chemically modified at the nucleic acid base, sugar, or backbone.
2 more elements
A nucleic acid molecule with catalytic activity having SEQ ID NO:
- 3.
A nucleic acid molecule with catalytic activity having SEQ ID NO:
- 4.
Dependencies are inferred from the claim text.