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US 2003/0144483 A1Published application
Humanized antibodies to Fc receptors for immunoglobulin G on human mononuclear phagocytes
AssigneeMedarex, Inc.
InventorsPhilip R. Tempest, William J. Harris, Frank J. Carr
Life of this patent
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Abstract
Humanized antibodies are described which are specific to an Fc receptor (FcR). The humanized antibodies have at least a portion of a complementarity determining region (CDR) derived from a non-human antibody, e.g., murine, with the remaining portions being human in origin. The humanized antibodies can be used therapeutically as is or formulated as bifunctional molecules or immunotoxins.
Claims28
A humanized antibody specific to an Fc receptor comprising:
- a human antibody having at least a portion of a complementarity determining region derived from a non-human antibody, the portion being selected to provide specificity of the humanized antibody for a human Fc receptor.
A bispecific molecule, comprising:
- at least one humanized antigen binding region derived from a humanized anti-Fc receptor antibody, and
- at least one antigen binding region specific for a target epitope.
Dependencies are inferred from the claim text.