Novel amphiphilic polymeric materials
AssigneeUniversity of Massachusetts, a Massachusetts corporation
InventorsArthur C. Watterson, Kunya Danprasert, Anil Diwan
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Abstract
The invention is based in part on the discovery of polymers that can complex with certain types of therapeutic drugs and transport those drugs across cell membranes in cell cultures with demonstrable therapeutic activity. The polymers are designed to overcome some of the known problems of liposomes as drug carriers. The polymers can be used in the development of physiologically stable, non-leaking, non-immunogenic, efficacious and safe targetable drug delivery systems (e.g., for delivery of anti-HIV or anticancer drugs).
Claims44
A polymer comprising a structure represented by:
- 6
- wherein R is hydrogen, a linear or branched alkyl group, a linear or branched alkenyl group, or an aryl group;
- wherein said alkyl, alkenyl, or aryl group is unsubstituted or substituted with one or more heteroatomic functional groups;
- R′ is hydrogen, an acyl group, an antibody fragment, a chemomimetic functional group, an immunoconjugate, a ligand for a biological target, or
- 7
- wherein R′″ is a hydroxyl group, an alkoxyl group, or a primary or secondary amino group;
- n is at least 1;
- and
- m is at least 1.
A polymer comprising a structure represented by:
- 8
- wherein R is hydrogen, a linear or branched alkyl group, a linear or branched alkenyl group, or an aryl group;
- wherein said alkyl, alkenyl, or aryl group is unsubstituted or substituted with one or more heteroatomic functional groups;
- R′ is hydrogen, an acyl group, an antibody fragment, a chemomimetic functional group, an immunoconjugate, a ligand for a biological target, or
- 9
- wherein R′″ is a hydroxyl group, an alkoxyl group, or a primary or secondary amino group;
- n is at least 1;
- and
- m is at least 1.
Dependencies are inferred from the claim text.