Degradable thiol-ene polymers
AssigneeThe Regents of the University of Colorado
InventorsChristopher Bowman, Kristi Anseth, Bilge Hacioglu, Charlie Nuttelman
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Abstract
A thiol-ene polymeric material is disclosed. The material is produced by the photopolymerization of reactants having thiol and olefin moieties. The material can incorporate encapsulated components, including cells. Additionally, the material can be derivatized by reacting the polymeric material with components such as proteins.
Claims38
A polymeric material comprising repeating units of the formula:
- —[—S—R1—S—C—C—R2—C—C]—
- wherein R1 and R2 are independent linkers, and at least one of R1 and R2 are degradable.
A method of preparation of a polymeric material, comprising:
- (i) combining a first reactant of the formula R1—(C═C)n with a second reactant of the formula R2—(SH)m, wherein n and m are independently integers greater than one and R1 and R2 are independently linking segments;
- and at least one of R1 and R2 are degradable segments;
- and
- (ii) irradiating the combined first and second reactants with light to cause reaction between the first and second reactants to form the polymeric material.
A thiol-ene hydrogel comprising poly(lactic acid), poly(ethylene glycol), and poly(vinyl alcohol) polymeric segments, wherein at least one of said segments has a degree of branching of greater than two and wherein said thiol-ene hydrogel has a modification selected from the group consisting of:
- encapsulation of at least one biologically active component within the thiol-ene hydrogel and derivatization of the thiol-ene hydrogel with a functional molecule.
Dependencies are inferred from the claim text.