Composition for the prevention and/or treatment of the cytotoxic effects induced by the use of immunosuppressive agents
AssigneeSigma-Tau Industrie Farmaceutiche Riunite S.p.A.
InventorClaudio Cavazza
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Abstract
A composition is disclosed which is suitable for the prevention and/or treatment of cell and tissue abnormalities of exogenous, toxic or metabolic origin and suitable for reducing the toxic effects of cyclosporin-A and other immunosuppressive agents, which may take the form of a food supplement or of an actual medicine, containing as its active ingredients in combination or separately packaged: (a) propionyl L-carnitine or one of its pharmacologically acceptable salts, and (b) an amino acid selected from the group consisting of glycine, serine, alanine and arginine, or mixtures thereof.
Claims16
A combination composition which comprises as active ingredients, in admixture or separately packaged, the following components:
- (a) propionyl L-carnitine or a pharmacologically acceptable salt thereof;
- and
- (b) an aminoacid selected from the group comprising glycine, alanine, arginine and serine or the pharmacologically acceptable salts thereof or mixtures thereof.
The composition of any of the preceding claims wherein the pharmacologically acceptable salt is selected from the group consisting of:
- chloride;
- bromide;
- iodide;
- aspartate, acid aspartate;
- citrate, acid citrate;
- tartrate;
- phosphate, acid phosphate;
- fumarate, acid fumarate;
- glycerophosphate;
- glucose phosphate;
- lactate;
- maleate, acid maleate;
- mucate;
- orotate;
- oxalate;
- acid oxalate;
- sulphate, acid sulphate;
- trichloroacetate;
- trifluoroacetate and methane sulphonate.
The composition of any of the preceding claims, which further comprises vitamins, coenzymes, mineral substances, aminoacids and antioxidants.
The composition of any of the preceding claims, orally administrable, in the form of a dietary supplement.
The composition of any of the preceding claims, orally, parenterally, rectally, sublingually or transdermally administrable, in the form of a medicament.
A method for the prevention and/or treatment of nephrotoxic, vasculotoxic or, generally, citotoxic lesions brought about by the use of immunosuppressants, particularly cyclosporin-A, tacrolimus, rapamicine and deoxyspargualine, which comprises administering to a subject in need thereof a combination composition comprising the following components:
- (a) propionyl L-carnitine or a pharmacologically acceptable salt thereof, and
- (b) an aminoacid selected from the group comprising glycine, alanine, arginine and serine or the pharmacologically acceptable salts thereof or mixtures thereof.
Dependencies are inferred from the claim text.