BTK inhibitors and methods for their identification and use
AssigneeParker Hughes Institute
InventorsFatih M. Uckun, Ravi Malaviya
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Abstract
The invention provides BTK inhibitors, methods for their identification and use, and pharmaceutical compositions comprising BTK inhibitors, including allergy treatments.
Claims32
A method to alter leukotriene production from mast cells, the method comprising contacting mast cells with an effective leukotriene-altering amount of a LFM analogue of the formula:
- 31
- where X comprises H, Br, Cl, F, CF3, or OCF3.
A method for treating or preventing asthma in a mammal, the method comprising administering to a mammal a therapeutically effective amount of a LFM analogue of the formula:
- 32
- where X comprises H, Br, Cl, F, CF3, or OCF3.
A method of altering the number of eosinophils in the bronchioles, the method comprising administering to a mammal a therapeutically effective amount of a LFM analogue of the formula:
- 33
- where X comprises H, Br, Cl, F, CF3, or OCF3.
A method for reducing bronchial hyperresponsiveness the method comprising administering administering to a mammal a therapeutically effective amount of a LFM analogue of the formula:
- 34
- where X comprises H, Br, Cl, F, CF3, or OCF3.
A method for treating allergy comprising administering to a patient a therapeutically effective amount of a leflunomide analog of the formula:
- 35
- where X comprises H, Br, Cl, F, CF3, or OCF3.
A method for treating anaphylactic shock comprising administering to a patient a therapeutically effective amount of a leflunomide analog of the formula:
- 36
- where X comprises H, Br, Cl, F, CF3, or OCF3.
Dependencies are inferred from the claim text.