Hydroperylene derivatives

A compound of formula I

• 4
• including all stereoisomeric forms of said compound of formula I, mixtures of said forms and compounds in any ratio, and/ physiologically tolerated salts thereof, wherein:
• R1, R2, R3, R4, R5, R6, R7, R8, R10 and R11 are independently selected from the group consisting of hydrogen;
• (C1-C6)-alkyl, in which alkyl is a straight or branched chain and is unsubstituted or substituted by one, two or three substituents independently selected from the group consisting of:
• —OH;
• ═O;
• —O—(C1-C6)-alkyl, in which alkyl is a straight or branched chain and is unsubstituted or substituted by one, two or three substituents independently selected from the group consisting of:
• —CN;
• —NH2;
• ═N—OH and ═N—O—(C1-C6)-alkyl, in which alkyl is a straight or branched chain;
• —O—(C2-C6)-alkenyl, in which alkenyl is a straight or branched chain and is unsubstituted or substituted by one, two or three substituents independently selected from the group consisting of:
• —CN;
• —NH2;
• ═N—OH and ═N—O—(C1-C6)-alkyl, in which alkyl is a straight or branched chain;
• —O—(C2-C6)-alkynyl, in which alkynyl is a straight or branched chain and is unsubstituted or substituted by one, two or three substituents independently selected from the group consisting of:
• :
• —CN;
• —NH2;
• ═N—OH and ═N—O—(C1-C6)-alkyl, in which alkyl is a straight or branched chain;
• -aryl, in which aryl is unsubstituted or substituted by one, two or three substituents independently selected from the group consisting of:
• halogen;
• —(C1-C4)-alkyl, in which alkyl is a straight or branched chain;
• —O—(C1-C6)-alkyl, in which alkyl is a straight or branched chain;
• —OH and —(C1-C4)-alkyl, in which alkyl is a straight or branched chain and is substituted by one, two or three substituents selected from the group consisting of halogen;
• —C(O)—OH;
• —C(O)—O—NH2;
• —C(O)—O—(C1-C4)-alkyl, in which alkyl is a straight or branched chain;
• —NH—(C1-C6)-alkyl, in which alkyl is a straight or branched chain and is unsubstituted or substituted by one, two or three substituents independently selected from the group consisting of:
• —CN;
• —NH2;
• ═N—OH and ═N—O—(C1-C6)-alkyl, in which alkyl is a straight or branched chain;
• —NH—(C2-C6)-alkenyl, in which alkenyl is a straight or branched chain and is unsubstituted or substituted by one, two or three substituents independently selected from the group consisting of:
• —CN;
• —NH2;
• ═N—OH and ═N—O—(C1-C6)-alkyl, in which alkyl is a straight or branched chain;
• —NH—(C2-C6)-alkynyl, in which alkynyl is a straight or branched chain and is unsubstituted or substituted by one, two or three substituents independently selected from the group consisting of:
• —CN;
• —NH2;
• ═N—OH and ═N—O—(C1-C6)-alkyl, in which alkyl is a straight or branched chain;
• —NH2 and halogen;
• (C2-C6)-alkenyl, in which alkenyl is a straight or branched chain and is unsubstituted or substituted by one, two or three substituents independently selected from the group consisting of:
• —OH;
• ═O;
• —O—(C1-C6)-alkyl, in which alkyl is a straight or branched chain and is unsubstituted or substituted by one, two or three substituents independently selected from the group consisting of:
• —CN;
• —NH2;
• ═N—OH and ═N—O—(C1-C6)-alkyl, in which alkyl is a straight or branched chain;
• —O—(C2-C6)-alkenyl, in which alkenyl is a straight or branched chain and is unsubstituted or substituted by one, two or three substituents independently selected from the group consisting of:
• —CN;
• —NH2;
• ═N—OH and ═N—O—(C1-C6)-alkyl, in which alkyl is a straight or branched chain;
• —O—(C2-C6)-alkynyl, in which alkynyl is a straight or branched chain and is unsubstituted or substituted by one, two or three substituents independently selected from the group consisting of:
• :
• —CN;
• —NH2;
• ═N—OH and ═N—O—(C1-C6)-alkyl, in which alkyl is a straight or branched chain;
• -aryl, in which aryl is unsubstituted or substituted by one, two or three substituents independently selected from the group consisting of:
• halogen;
• —(C1-C4)-alkyl, in which alkyl is a straight or branched chain;
• —O—(C1-C6)-alkyl, in which alkyl is a straight or branched chain;
• —OH and —(C1-C4)-alkyl, in which alkyl is a straight or branched chain and is substituted one, two or three times by halogen;
• —C(O)—OH;
• —C(O)—O—NH2;
• —C(O)—O—(C1-C4)-alkyl, in which alkyl is a straight or branched chain;
• —NH—(C1-C6)-alkyl, in which alkyl is a straight or branched chain and is unsubstituted or substituted by one, two or three substituents independently selected from the group consisting of:
• —CN;
• —NH2;
• ═N—OH and ═N—O—(C1-C6)-alkyl, in which alkyl is a straight or branched chain;
• —NH—(C2-C6)-alkenyl, in which alkenyl is a straight or branched chain and is unsubstituted or substituted by one, two or three substituents independently selected from the group consisting of:
• —CN;
• —NH2;
• ═N—OH and ═N—O—(C1-C6)-alkyl, in which alkyl is a straight or branched chain;
• —NH—(C2-C6)-alkynyl, in which alkynyl is a straight or branched chain and is unsubstituted or substituted by one, two or three substituents independently selected from the group consisting of:
• —CN;
• —NH2;
• ═N—OH and ═N—O—(C1-C6)-alkyl, in which alkyl is a straight or branched chain;
• —NH2 and halogen;
• (C2-C6)-alkynyl, in which alkynyl is a straight or branched chain and is unsubstituted or substituted by one, two or three substituents independently selected from the group consisting of:
• —OH;
• ═O;
• —O—(C1-C6)-alkyl, in which alkyl is a straight or branched chain and is unsubstituted or substituted by one, two or three substituents independently selected from the group consisting of:
• —CN;
• —NH2;
• ═N—OH and ═N—O—(C1-C6)-alkyl, in which alkyl is a straight or branched chain;
• —O—(C2-C6)-alkenyl, in which alkenyl is a straight or branched chain and is unsubstituted or substituted by one, two or three substituents independently selected from the group consisting of:
• —CN;
• —NH2;
• ═N—OH and ═N—O—(C1-C6)— alkyl, in which alkyl is a straight or branched chain;
• —O—(C2-C6)-alkynyl, in which alkynyl is a straight or branched chain and is unsubstituted or substituted by one, two or three substituents independently selected from the group consisting of:
• —CN;
• —NH2;
• ═N—OH and ═N—O—(C1-C6)-alkyl, in which alkyl is a straight or branched chain;
• -aryl, in which aryl is unsubstituted or substituted by one, two or three substituents independently selected from the group consisting of:
• halogen;
• —(C1-C4)-alkyl, in which alkyl is a straight or branched chain;
• —O—(C1-C6)-alkyl, in which alkyl is a straight or branched chain;
• —OH and —(C1-C4)-alkyl, in which alkyl is a straight or branched chain and is substituted one, two or three times by halogen;
• —C(O)—OH;
• —C(O)—O—NH2;
• —C(O)—O—(C1-C4)-alkyl, in which alkyl is a straight or branched chain;
• —NH—(C1-C6)-alkyl, in which alkyl is a straight or branched chain and is unsubstituted or substituted by one, two or three substituents independently selected from the group consisting of:
• —CN;
• —NH2;
• ═N—OH and ═N—O—(C1-C6)-alkyl, in which alkyl is a straight or branched chain;
• —NH—(C2-C6)-alkenyl, in which alkenyl is a straight or branched chain and is unsubstituted or substituted by one, two or three substituents independently selected from the group consisting of:
• —CN;
• —NH2;
• ═N—OH and ═N—O—(C1-C6)-alkyl, in which alkyl is a straight or branched chain;
• —NH—(C2-C6)-alkynyl, in which alkynyl is a straight or branched chain and is unsubstituted or substituted by one, two or three substituents independently selected from the group consisting of:
• —CN;
• —NH2;
• ═N—OH and ═N—O—(C1-C6)-alkyl, in which alkyl is a straight or branched chain;
• —NH2 and halogen;
• —O—R9, in which R9 is selected from the group consisting of:
• (C1-C6)-alkyl, in which alkyl is a straight or branched chain and is unsubstituted or substituted by one, two or three substituents independently selected from the group consisting of:
• —OH;
• ═O;
• —O—(C1-C6)-alkyl, in which alkyl is a straight or branched chain and is unsubstituted or substituted by one, two or three substituents independently selected from the group consisting of:
• —CN;
• —NH2;
• ═N—OH;
• and ═N—O—(C1-C6)-alkyl, in which alkyl is a straight or branched chain;
• —O—(C2-C6)-alkenyl, in which alkenyl is a straight or branched chain and is unsubstituted or substituted by one, two or three substituents independently selected from the group consisting of:
• —CN;
• —NH2;
• ═N—OH and ═N—O—(C1-C6)-alkyl, in which alkyl is a straight or branched chain;
• —O—(C2-C6)-alkynyl, in which alkynyl is a straight or branched chain and is unsubstituted or substituted by one, two or three substituents independently selected from the group consisting of:
• —CN;
• —NH2;
• ═N—OH and ═N—O—(C1-C6)-alkyl, in which alkyl is a straight or branched chain;
• -aryl, in which aryl is unsubstituted or substituted by one, two or three substituents independently selected from the group consisting of:
• halogen;
• —(C1-C4)-alkyl, in which alkyl is a straight or branched chain;
• —O—(C1-C6)-alkyl, in which alkyl is a straight or branched chain;
• —OH and —(C1-C4)-alkyl, in which alkyl is a straight or branched chain and is substituted one, two or three times by halogen;
• —C(O)—OH;
• —C(O)—O—NH2;
• —C(O)—O—(C1-C4)-alkyl, in which alkyl is a straight or branched chain;
• —NH—(C1-C6)-alkyl, in which alkyl is a straight or branched chain and is unsubstituted or substituted by one, two or three substituents independently selected from the group consisting of:
• —CN;
• —NH2;
• ═N—OH;
• and ═N—O—(C1-C6)-alkyl, in which alkyl is a straight or branched chain;
• —NH—(C2-C6)-alkenyl, in which alkenyl is a straight or branched chain and is unsubstituted or substituted by one, two or three substituents independently selected from the group consisting of:
• —CN;
• —NH2;
• ═N—OH and ═N—O—(C1-C6)-alkyl, in which alkyl is a straight or branched chain;
• —NH—(C2-C6)-alkynyl, in which alkynyl is a straight or branched chain and is unsubstituted or substituted by one, two or three substituents independently selected from the group consisting of:
• —CN;
• —NH2;
• ═N—OH and ═N—O—(C1-C6)-alkyl, in which alkyl is a straight or branched chain;
• —NH2 and halogen;
• (C2-C6)-alkenyl, in which alkenyl is a straight or branched chain and is unsubstituted or substituted by one, two or three substituents independently selected from the group consisting of:—OH;
• ═O;
• —O—(C1-C6)-alkyl, in which alkyl is a straight or branched chain and is unsubstituted or substituted by one, two or three substituents independently selected from the group consisting of:
• —CN;
• —NH2;
• ═N—OH;
• and ═N—O—(C1-C6)-alkyl, in which alkyl is a straight or branched chain;
• —O—(C2-C6)-alkenyl, in which alkenyl is a straight or branched chain and is unsubstituted or substituted by one, two or three substituents independently selected from the group consisting of:
• —CN;
• —NH2;
• ═N—OH and ═N—O—(C1-C6)-alkyl, in which alkyl is a straight or branched chain;
• —O—(C2-C6)-alkynyl, in which alkynyl is a straight or branched chain and is unsubstituted or substituted by one, two or three substituents independently selected from the group consisting of:
• —CN;
• —NH2;
• ═N—OH and ═N—O—(C1-C6)-alkyl, in which alkyl is a straight or branched chain;
• -aryl, in which aryl is unsubstituted or substituted by one, two or three substituents independently selected from the group consisting of:
• halogen;
• —(C1-C4)-alkyl, in which alkyl is a straight or branched chain;
• —O—(C1-C6)-alkyl, in which alkyl is a straight or branched chain;
• —OH and —(C1-C4)-alkyl, in which alkyl is a straight or branched chain and is substituted one, two or three times by halogen;
• —C(O)—OH;
• —C(O)—O—NH2;
• —C(O)—O—(C1-C4)-alkyl, in which alkyl is a straight or branched chain;
• —NH—(C1-C6)-alkyl, in which alkyl is a straight or branched chain and is unsubstituted or substituted by one, two or three substituents independently selected from the group consisting of:
• —CN;
• —NH2;
• ═N—OH;
• and ═N—O—(C1-C6)-alkyl, in which alkyl is a straight or branched chain;
• —NH—(C2-C6)-alkenyl, in which alkenyl is a straight or branched chain and is unsubstituted or substituted by one, two or three substituents independently selected from the group consisting of:
• —CN;
• —NH2;
• ═N—OH and ═N—O—(C1-C6)-alkyl, in which alkyl is a straight or branched chain;
• —NH—(C2-C6)-alkynyl, in which alkynyl is a straight or branched chain and is unsubstituted or substituted by one, two or three substituents independently selected from the group consisting of:
• —CN;
• —NH2;
• ═N—OH and ═N—O—(C1-C6)-alkyl, in which alkyl is a straight or branched chain;
• —NH2 and halogen;
• (C2-C6)-alkynyl, in which alkynyl is a straight or branched chain and is unsubstituted or substituted by one, two or three substituents independently selected from the group consisting of:—OH;
• ═O;
• —O—(C1-C6)-alkyl, in which alkyl is a straight or branched chain and is unsubstituted or substituted by one, two or three substituents independently selected from the group consisting of:
• —CN;
• —NH2;
• ═N—OH;
• and ═N—O—(C1-C6)-alkyl, in which alkyl is a straight or branched chain;
• —O—(C2-C6)-alkenyl, in which alkenyl is a straight or branched chain and is unsubstituted or substituted by one, two or three substituents independently selected from the group consisting of:
• —CN;
• —NH2;
• ═N—OH and ═N—O—(C1-C6)-alkyl, in which alkyl is a straight or branched chain;
• —O—(C2-C6)-alkynyl, in which alkynyl is a straight or branched chain and is unsubstituted or substituted by one, two or three substituents independently selected from the group consisting of:
• —CN;
• —NH2;
• ═N—OH and ═N—O—(C1-C6)-alkyl, in which alkyl is a straight or branched chain;
• -aryl, in which aryl is unsubstituted or substituted by one, two or three substituents independently selected from the group consisting of:
• halogen;
• —(C1-C4)-alkyl, in which alkyl is a straight or branched chain;
• —O—(C1-C6)-alkyl, in which alkyl is a straight or branched chain;
• —OH and —(C1-C4)-alkyl, in which alkyl is a straight or branched chain and is substituted one, two or three times by halogen;
• —C(O)—OH;
• —C(O)—O—NH2;
• —C(O)—O—(C1-C4)-alkyl, in which alkyl is a straight or branched chain;
• —NH—(C1-C6)-alkyl, in which alkyl is a straight or branched chain and is unsubstituted or substituted by one, two or three substituents independently selected from the group consisting of:
• —CN;
• —NH2;
• ═N—OH;
• and ═N—O—(C1-C6)-alkyl, in which alkyl is a straight or branched chain;
• —NH—(C2-C6)-alkenyl, in which alkenyl is a straight or branched chain and is unsubstituted or substituted by one, two or three substituents independently selected from the group consisting of:
• —CN;
• —NH2;
• ═N—OH and ═N—O—(C1-C6)-alkyl, in which alkyl is a straight or branched chain;
• —NH—(C2-C6)-alkynyl, in which alkynyl is a straight or branched chain and is unsubstituted or substituted by one, two or three substituents independently selected from the group consisting of:
• —CN;
• —NH2;
• ═N—OH and ═N—O—(C1-C6)-alkyl, in which alkyl is a straight or branched chain;
• —NH2 and halogen;
• —NH—R9, in which R9 is as defined above;
• —NH—C(O)—H;
• —NH—C(O)—R9, in which R9 is as defined above;
• —NH-aryl, in which aryl is unsubstituted or independently substituted one, two or three times by R9, in which R9 is as defined above:
• ═N—OH;
• ═N—O—R9, in which R9 is as defined above;
• —S—H;
• —S—R9, in which R9 is as defined above;
• —S(O)—R9, in which R9 is as defined above;
• —S(O)2—R9, in which R9 is as defined above;
• and
• —SO2, with the following further alternatives to the foregoing definition:
• a) either R4 and R5 or R10 and R11, together with the carbon atoms to which they are,respectively, bonded, may form a 3-, 4-, 5- or 6-membered heteroalkyl or heteroaryl ring system which contains one or two heteroatoms selected from the group consisting of oxygen, nitrogen and sulfur;
• and
• b) the bond between the ring carbons indicated as —C14-C15— in formula I may be either a single bond or a double bond;
• and the further proviso that:
• c) R7 is not hydrogen.