Methods and compositions for regulation of 5-alpha reductase activity
OwnerShutsung Liao, Richard A. Hiipakkainventors
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Abstract
Compounds that inhibit 5α-reductase are provided. The compounds are used to treat prostate cancer, breast cancer, obesity, skin disorders and baldness.
Claims11
A process of inhibiting 5α-reductase activity comprising the step of exposing 5α-reductase to an effective inhibiting amount of a compound of any of Tables 1-7.
A process of treating prostate cancer in a subject in need of such treatment comprising the step of administering to the subject an effective therapeutic amount of a compound of any of Tables 1-7.
A process of treating breast cancer in a subject in need of such treatment comprising the step of administering to the subject an effective therapeutic amount of a compound of any of Tables 1-7.
A process of treating baldness in a subject in need of such treatment comprising the step of administering to the subject an effective therapeutic amount of a compound of any of Tables 1-7.
A process of treating a skin disorder in a subject in need of such treatment comprising the step of administering to the subject an effective therapeutic amount of a compound of any of Tables 1-7.
A process of treating obesity in a subject in need of such treatment comprising the step of administering to the subject an effective therapeutic amount of a compound of any of Tables 1-7.
A process of treating benign prostatic hyperplasia or prostatitis in a subject in need of such treatment comprising the step of administering to the subject an effective therapeutic amount of a compound of any of Tables 1-7.
A compound of the formula:
- 4
- where x is —NHCH2CH2— or —CH═CH—;
- R1, R2 and R3 each may be —H, —OH or —OCH3, provided that only one of R1, R2, and R3 may be —H;
- R4, R5 and R6 each may be —H, —OH, —OCH3 or —N(CH3)2, provided that only one of R4, R5 and R6 may be —H;
- and
- n is 0 or 1.
A compound of the formula:
- 5
- where R is a chain with 2 to 20 atoms from the group consisting of carbon, oxygen, sulfur, and nitrogen, without or with one to four double bonds and additional hydrogen.
A compound of the formula:
- 6
- where R is
- 7
A method for the stabilization of compounds shown in Tables 1-7 comprising adding an effective ambient of an inorganic acid, an organic acid, or a natural product that contains these acids to maintain the acidity of the therapeutic preparations of these compounds at pH 3.0 to pH 6.8.
Dependencies are inferred from the claim text.