Treatment of metabolic diseases with soraphen derivatives
OwnerMarcel Gubler, Jacques Mizrahiinventors
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Abstract
The present invention relates to the use of Soraphen derivatives and pharmaceutically acceptable esters thereof, for the treatment and/or prophylaxis of diseases which are associated with ACCβ activity and/or fatty acid oxidation such as diabetes, obesity and dyslipidemia.
Claims15
A pharmaceutical composition for the treatment or prophylaxis of diseases associated with ACCβ activity, fatty acid oxidation or both comprising a compound of the formula
- 6
- wherein
- R1 is hydrogen or hydroxy,
- R2 is hydrogen or lower-alkyl,
- R3 is hydrogen or lower-alkyl,
- and pharmaceutically acceptable esters thereof,
- and at least one pharmaceutically acceptable carrier or adjuvant or combinations thereof.
A method for the treatment or prophylaxis of a disease associated with ACCβ activity, fatty acid oxidation or both, which method comprises administering to a human being or other animal a pharmaceutically effective amount of a compound of the formula
- 10
- wherein
- R1 is hydrogen or hydroxy,
- R2 is hydrogen or lower-alkyl,
- R3 is hydrogen or lower-alkyl,
- and pharmaceutically acceptable esters thereof.
Dependencies are inferred from the claim text.