p-thienylbenzylamides as agonists of angiotensin-(1-7) receptors, and methods of their preparation and use

A compound of formula (I)

• 41
• in which the indicated radicals have the following meanings:
• R(1) is chosen from among
• 1. (C1-C5)-alkyl, unsubstituted or substituted by a radical chosen from among NH2, halogen, O—(C1-C3)-alkyl, CO—O—(C1-C3)-alkyl and CO2H;
• 2. (C3-C8)-cycloalkyl;
• 3. (C1-C3)-alkyl-(C3-C8)-cycloalkyl;
• 4. (C6-C10)-aryl, unsubstituted or substituted by a radical chosen from halogen and O—(C1-C3)-alkyl;
• 5. (C1-C3)-alkyl-(C6-C10)-aryl, where the aryl radical is unsubstituted or substituted by a radical chosen from halogen and O—(C1-C3)-alkyl;
• 6. (C1-C5)-heteroaryl;
• and
• 7. (C1-C3)-alkyl-(C1-C5)-heteroaryl;
• R(2) is chosen from among
• 1. hydrogen;
• 2. (C1-C6)-alkyl, unsubstituted or substituted by a radical chosen from halogen and O—(C1-C3)-alkyl;
• 3. (C3-C8)-cycloalkyl;
• 4. (C1-C3)-alkyl-(C3-C8)-cycloalkyl;
• 5. (C6-C10)-aryl, unsubstituted or substituted by a radical chosen from among halogen, O—(C1-C3)-alkyl and CO—O—(C1-C3)-alkyl;
• and
• 6. (C1-C3)-alkyl-(C6-C10)-aryl, unsubstituted or substituted by a radical chosen from halogen and O—(C1-C3)-alkyl;
• R(3) is chosen from among
• 1. hydrogen;
• 2. COOH;
• and
• 3. COO—(C1-C4)-alkyl;
• R(4) is chosen from among
• 1. hydrogen;
• 2. halogen;
• and
• 3. (C1-C4)-alkyl;
• R(5) is chosen from
• 1. hydrogen, and
• 2. (C1-C6)-alkyl;
• R(6) is chosen from among
• 1. hydrogen;
• 2. (C1-C6)-alkyl;
• 3. (C1-C3)-alkyl-(C3-C8)-cycloalkyl;
• and
• 4. (C2-C6)-alkenyl;
• X is chosen from
• 1. oxygen,and
• 2. NH;
• in all the stereoisomeric forms thereof, and mixtures thereof in all ratios, and the physiologically tolerated salts thereof.