Indole derivatives as mcp-1 receptor antagonists
OwnerAlan Wellington Faull, Jason Grant Kettleinventors
Life of this patent
Estimating the term…
Abstract
A compound of formula (I) wherein: R1 is hydrogen, halo or methoxy; R2 is hydrogen, halo, methyl, ethyl or methoxy; R3 is a halo group or a trifluoromethyl group; R4 is a halo group or a trifluoromethyl group; R5 is hydrogen or halo; R6 is hydrogen or halo; provided that when R5 and R6 are both hydrogen, and one of R3 or R4 is chloro or fluoro, then the other is not chloro or fluoro; or a pharmaceutically acceptable salt or prodrug thereof. These compounds have useful activity for the treatment of inflammatory disease, specifically in antagonising an MCP-1 mediated effect in a warm-blooded animal such as a human being.
Claims14
A compound of the formula (I):
- 15
- wherein:
- R1 is hydrogen, halo or methoxy,
- R2 is hydrogen, halo, methyl, ethyl or methoxy;
- R3 is a halo group or a trifluoromethyl group;
- R4 is a halo group or a trifluoromethyl group;
- R5 is hydrogen or halo;
- R6 is hydrogen or halo;
- provided that when R5 and R6 are both hydrogen, and one of R3 or R4 is chloro or fluoro, then the other is not chloro or fluoro;
- or a pharmaceutically acceptable salt or prodrug thereof.
Dependencies are inferred from the claim text.