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US 2003/0144333 A1Published application
Thiophenyl triazol-3-one derivatives as smooth muscle relaxants
AssigneeBristol-Myers Squibb Company
InventorsPiyasena Hewawasam, John E. Starrett, Dalton King, Li-Quang Sun, Nicholas J. Lodge
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Abstract
The present invention provides novel [1,2,4]triazole-3-one derivatives having the general formula (I) 1 wherein: Q is 2 and R1, R2, R3, R4, R5 and R6 are as defined herein or a nontoxic pharmaceutically acceptable salt or solvate thereof which are smooth muscle relaxants and useful in treating disorders responsive to relaxation of smooth muscle such as asthma, irritable bowel syndrome, male erectile dysfunction and urinary incontinence.
Claims21
A compound of formula I
- 36
- wherein:
- Q is
- 37
- R1 and R2 are each independently selected from the group consisting of hydrogen, halogen, C1-6alkyl and C2-6alkenyl;
- R3 is halogen or trifluoromethyl;
- and
- R4, R5 and R6 are each independently selected from the group consisting of hydrogen, halogen and C1-6alkyl;
- or a nontoxic pharmaceutically acceptable salt or solvate thereof.
6 more elements
Dependencies are inferred from the claim text.