Diarylcycloalkyl derivatives, processes for their preparation and their use s pharmaceuticals
AssigneeAventis Pharma Deutschland GmbH
InventorsHeiner Glombik, Eugen Falk, Wendelin Frick, Stefanie Keil, Hans-Ludwig Schafer, Lothar Schwink, Wolfgang Wendler
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Abstract
Diarylcycloalkyl derivatives and their physiologically acceptable salts and physiologically functional derivatives are disclosed. The compounds include those of formula I, 1 in which the radicals are as defined, and their physiologically acceptable salts and processes for their preparation. The compounds typically have lipid- and/or triglyceride-lowering properties and are suitable, for example, for the treatment of disorders of lipid metabolism, of type II diabetes, and of syndrome X.
Claims23
A compound of formula I
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- in which
- Ring A is (C3-C8)-cycloalkyl or (C3-C8)-cycloalkenyl where, in the cycloalkyl or cycloalkenyl rings, one or more carbon atoms may be replaced by oxygen atoms;
- R1, R2, R4, R5 independently of one another are H, F, Cl, Br, OH, NO2, CF3, OCF3, (C1-C6)-alkyl or O—(C1-C6)-alkyl;
- R3 is H or (C1-C6)-alkyl;
- X is (C1-C6)-alkyl where, in the alkyl group, one or more carbon atoms may be replaced by oxygen atoms;
- Y is (C1-C6)-alkyl where, in the alkyl group, one or more carbon atoms may be replaced by oxygen atoms;
- and its physiologically acceptable salts.
A compound of formula Ia
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- wherein
- Ring A is cyclohexyl;
- R1, R2 independently of one another are H, F, Cl, Br, OH, NO2, CF3, OCF3, (C1-C6)-alkyl or O—(C1-C6)-alkyl;
- R3 is H or (C1-C6)-alkyl;
- X is (C1-C6)-alkyl where, in the alkyl group, one or more carbon atoms may be replaced by oxygen atoms;
- Y is (C1-C6)-alkyl where, in the alkyl group, one or more carbon atoms may be replaced by oxygen atoms;
- and its physiologically acceptable salts.
Dependencies are inferred from the claim text.