p53 inhibitors and therapeutic use of the same
AssigneeThe Board of Trustees of the University of Illinois
InventorsAndrei V. Gudkov, Pavel G. Komarov, Elena A. Komarova
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Abstract
The therapeutic use of temporary p53 inhibitors in the treatment of p53-mediated diseases, conditions, and injuries is disclosed.
Claims45
A method of treating a disease or condition wherein inhibition of p53 activity provides a benefit comprising administering a therapeutically effective amount of a temporary p53 inhibitor to an individual suffering from the disease or condition.
A method of reducing or eliminating normal cell death attributable to a treatment of a disease or condition comprising administering a therapeutically effective amount of a temporary p53 inhibitor to a mammal to reversibly inhibit p53 activity.
A method of reducing or eliminating normal cell death attributable to contraction of a disease comprising administering a therapeutically effective amount of a temporary p53 inhibitor to a mammal to reversibly inhibit p53 activity.
A method of reducing or eliminating damage to normal tissue attributable to a treatment for cancer comprising administering a therapeutically effective of a temporary p53 inhibitor to a mammal to reversibly inhibit p53 activity.
A cancer treatment composition comprising:
- (a) a chemotherapeutic drug;
- and
- (b) a temporary p53 inhibitor.
An improved method of treating cancer comprising administration of a therapeutically effective radiation dose to a mammal to treat a cancer, and administration of a therapeutically effective amount of a temporary p53 inhibitor to the mammal to reversibly inhibit p53 activity.
A method of preventing cell death attributable to a stress-inducing event affecting the cell, said method comprising treating the cell with therapeutically effective of a compound of a temporary p53 inhibitor to reversibly inhibit p53 activity.
A pharmaceutical composition for treating a disease comprising
- (a) a drug capable of treating the disease, and
- (b) a temporary p53 inhibitor.
A pharmaceutical composition comprising
- (a) a temporary p53 inhibitor, and
- (b) a carrier.
A method of modulating tissue aging comprising treating the tissue with a therapeutically effective amount of a temporary p53 inhibitor to reversibly inhibit p53 activity.
A method of sensitizing p53-deficient cells to a cancer therapy comprising administering, in conjunction with the cancer therapy, a sufficient amount of a temporary p53 inhibitor to a mammal to destroy p53-deficient cells that survive in an absence of the p53 inhibitor.
An improved method of treating cancer comprising administration of a therapeutically effective dose of a chemotherapeutic agent to a mammal to treat a cancer, and administration of a sufficient amount of a temporary p53 inhibitor to the mammal to reversibly inhibit p53 activity, wherein the dose of the chemotherapeutic agent is greater than a dose of the identical chemotherapeutic agent required to treat the cancer in the absence of administration of the p53 inhibitor.
A method of reducing or eliminating p53-mediated side effects associated with a cancer therapy comprising administering a therapeutically effective dose of a temporary p53 inhibitor to a mammal in conjunction with the cancer therapy.
Dependencies are inferred from the claim text.