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US 2003/0144327 A1Published application
Polymorphic, amorphous and hydrated forms of 5-chloro-3-(4-methanesulfonylphenyl)-6'-methyl-[2,3']bipyridinyl
AssigneeMerck & Co., Inc.
InventorLouis S. Crocker
Life of this patent
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Abstract
Polymorphic, amorphous and hydrated forms of the title compound having the following structure: 1 are disclosed. The compound is a potent and selective cyclooxygenase -2 (COX-2) inhibitor.
Claims9
A polymorph of Compound A of structural formula:
- 3
- selected from Forms II, III and IV having the physical characteristics described in the following Table:
- 3 Form II III IV DSC 134-136° C. 133° C. 134° C. extrapolated melting temperature onset XRPD (peak 5.6 10.5 8.7 positions, Cu K 9.4 16.1 15.2 alpha) 10.7 22.4 17.1 17.6 19.5 21.7 23.5 23.6
A sesquihydrate of Form I having a DSC of about 134-136° C., peak m.p. 138° C., an XRPD pattern of 7.1, 9.7, 11.8, 15.5, 20.1, 22.7 and 24.1, and further containing approximately 1.5 mol water per mol of compound A.
A Form II polymorph of Compound A of structural formula:
- 4
- having a DSC extrapolated melting temperature onset of ˜131° C., and XRPD peak positions, Cu K alpha of 5.6, 9.4, 10.7 and 17.6.
Dependencies are inferred from the claim text.