Novel benzoylecgonine compositions and methods for producing them
AssigneeEntropin, Inc.
InventorNicholas James Archer
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Abstract
This invention provides a method for preparing a benzoylecgonine composition comprising the steps of: (a) contacting benzoylmcthylecgonine and propylene glycol in the presence or absence of water to form a reaction mixture; (b) maintaining the reaction mixture at a temperature between about 500 and 100° C.; and (c) subsequently or simultaneously removing water from the reaction mixture. This invention also provides novel benzoylecgonine and methods for producing them.
Claims10
A method for preparing a benzoylecgonine composition comprising the steps of:
- (a) contacting benzoylmethylecgonine and propylene glycol in the presence or absence of water to form a reaction mixture;
- (b) maintaining the reaction mixture at a temperature between about 50° and 100° C. until substantially all of the benzoylmethylecgonine has reacted;
- and
- (c) subsequently or simultaneously removing water from the reaction mixture.
A benzoylecgonine composition comprising benzoylecgonine, ecgonidine, 2-hydroxypropyl benzoylecgonine esters and 2-hydroxypropyl ecgonidine esters wherein the composition comprises at least about 2% 2-hydroxypropyl benzoylecgonine esters and at least about 2% 2-hydroxypropyl ecgonidine esters.
Dependencies are inferred from the claim text.