Loading patent…
AssigneeKosan Biosciences, Inc.
InventorsDaniel Chu, Maria Fardis, Chaitan Khosla, Christopher Reeves, Daniel Santi, Andreas Schirmer
Estimating the term…
The present invention relates to novel polyketides, host cells that produce the novel compounds, and methods fort their use. The compounds of the present invention are cyclic polyketides (also referred to as a “macrolides” or “macrolactones”) that include 1 as part of their structure and bind to a FK binding protein wherein R4 and R5 are each selected from the group consisting of hydrogen, methyl, ethyl, and methoxy, provided that at least one of R4 and R5 is hydrogen, methyl, or ethyl. As will be explained in greater detail below, the compounds of the present invention have properties such as favorable P450 enzyme activity profiles that are desirable for use of these compounds as drugs.
A lactone having a Kd in a FKBP binding assay of approximately equal to or less than 1 μM and including a fragment
A compound of the formula
A recombinant host cell selected from the group consisting of KOS-45-170 (PTA-1811);
A compound produced by a recombinant host cell selected from the group consisting of KOS-45-170 (PTA-1811);
Dependencies are inferred from the claim text.