Inhibitors of Src and other protein kinases

A compound of formula I:

• 68
• or a pharmaceutically acceptable derivative thereof, wherein:
• G is —XR or —XAr;
• each X is independently selected from a C1-6 alkylidene chain wherein one or two non-adjacent methylene units of X are indpendently replaced by —O—, —NR—, —S—, —C(O)—, —C(O)NR—, —NRC(O)—, —NRC(O)NR—, —SO—, —SO2—, —NRSO2—, —SO2NR—, or —NRSO2NR—;
• A is N or CR;
• each R is independently selected from hydrogen or an optionally substituted C1-8 aliphatic group, or
• two R groups bound to the same nitrogen are taken together with the nitrogen to form a 3-7 membered heterocyclic ring having 0-2 heteroatoms, in addition to the nitrogen atom bound thereto, independently selected from nitrogen, oxygen, or sulfur;
• provided that when G is —N(R)2, the two R groups are not taken together to form a ring;
• Ar is an optionally substituted 5-6 membered saturated, partially unsaturated, or fully unsaturated monocyclic ring having zero to three heteroatoms independently selected from nitrogen, sulfur, or oxygen, or an optionally substituted 8-10 membered saturated, partially unsaturated, or fully unsaturated bicyclic ring having zero to four heteroatoms independently selected from nitrogen, sulfur, or oxygen;
• R1 is T(n)—R or T(n)—Ar;
• n is zero or one;
• T is selected from —C(O)—, —CO2—, —C(O)C(O)—, —C(O)CH2C(O)—, —CONR—, —S(O)2—, or —S(O)2NR—;
• R2 is selected from hydrogen, Ar, or a C1-8 aliphatic group optionally substituted with 1-3 groups independently selected from oxo, OR, SR, SO2R, C(O)R, CO2R, CN, N(R)2, ═N—OR, ═NN(R)2, ═NNHC(O)R, ═NNHCO2R, ═NNHSO2R, Ar, NRC(O)N(R)2, NRC(O)R, NRCO2R, C(O)N(R)2, SO2N(R)2, or NRSO2N(R)2;
• and
• R3 is selected from R or Ar.