US 2003/0144308 A1Published application

Fructose 1,6-bisphosphatase inhibitors

OwnerPaul H. Bauer, Stephen W. Wright +1inventors

InventorsPaul H. Bauer, Stephen W. Wright, Rodney C. Schnur

Life of this patent

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Abstract

The present invention relates to certain quinazoline compounds which have utility in the treatment of diabetes mellitus, hypercholesterolemia, hyperlipidemia, diabetic complications and cancer. The invention also relates to pharmaceutical compositions and kits comprising such quinazoline compounds and to methods of using such compounds in the treatment of diabetes mellitus, hypercholesterolemia, hyperlipidemia, diabetic complications and cancer.

Claims14

Dependent claims

A compound of the formula

11
a prodrug thereof or a pharmaceutically acceptable salt of said compound or said prodrug, wherein:
Q is pyrrolyl, pyrazolyl, oxazolyl, thiazolyl, isoxazolyl, isothiazolyl, oxadiazolyl, thiadiazolyl, triazolyl, furyl, quinolyl, imidazolyl, pyridyl or pyrimidyl;
T1 is hydrogen, methyl, ethyl, ORR10, SRR10, cyano, cyclopropyl, cyclobutyl, NH2, NHRR10,
N(R10)2, NHNH2, CHRR10OH, CH20RR10, COCH3 or CON(R10)2;
R1, R2, R3 and R4 are each independently hydrogen, halo, trifluoromethyl, (C1-C4)alkyl or (C1-C4)alkoxy;
R5and R8 are each independently hydrogen, fluoro, chloro, hydroxy or methyl;
R6 and R7 are each independently (C1-C4)alkyl or (C1-C4)alkoxy;
R9 is hydrogen, cyclopropyl, cyclobutyl, (C1-C4)alkyl or (CH2)m—Y;
R10, for each occurrence, is independently hydrogen, methyl or ethyl;
m is 1 , 2, 3 or 4;
Y is fluoro, chloro, bromo, hydroxy, N(R11)2, N-methylpiperazin-1-yl, thiazolidin-3-yl, thiomorpholin-4-yl, piperidin-1-yl, pyrrolidin-1-yl, morpholin-4-yl, imidazol-1-yl, (C1-C4)alkoxy, SR11, SOR11, SO2R11, CO2H, CO2(C1-C4)alkyl or CON(R11)2;
and
R11, for each occurrence, is independently hydrogen or (C1-C4)alkyl.

11 more elements

A compound selected from (6,7-diethoxy-quinazolin-4-yl)-(3-[1,2,4]oxadiazol-3-yl-phenyl)-amine;

(6,7-diethoxy-quinazolin-4-yl)-(3-oxazol-4-yl-phenyl)-amine;
(6,7-diethoxy-quinazolin-4-yl)-[3-(2-methyl-thiazol-4-yl)-phenyl]-amine;
[3-(2-amino-thiazol-4-yl)-phenyl]-(6,7-diethoxy-quinazolin-4-yl)-amine;
(6,7-diethoxy-quinazolin-4-yl)-(3-thiazol-4-yl-phenyl)-amine;
(6,7-diethoxy-quinazolin-4-yl)-[3-(2-methyl-oxazol-5-yl)-phenyl]-amine;
(6,7-diethoxy-quinazolin-4-yl)-(3-pyrimidin-5-yl-phenyl)-amine;
(6,7-diethoxy-quinazolin-4-yl)-[3-(2H-pyrazol-3-yl)-phenyl]-amine;
(6,7-diethoxy-quinazolin-4-yl)-(3-thiazol-5-yl-phenyl)-amine;
(6,7-diethoxy-quinazolin-4-yl)-(3-thiazol-2-yl-phenyl)-amine;
(6,7-dimethoxy-quinazolin-4-yl)-(3-thiazol-2-yl-phenyl)-amine;
(6,7-diethoxy-quinazolin-4-yl)-(3-furan-2-yl-phenyl)-amine;
(6,7-dimethoxy-quinazolin-4-yl)-(3-furan-2-yl-phenyl)-amine;
(6,7-diethoxy-quinazolin-4-yl)-(3-oxazol-2-yl-phenyl)-amine;
(6,7-diethoxy-quinazolin-4-yl)-[3-(2H-[1,2,4]triazol-3-yl)-phenyl]-amine;
(6,7-diethoxy-quinazolin-4-yl)-[3-(2-methyl-2H-[1,2,4]triazol-3-yl)-phenyl]-amine;
(6,7-dimethoxy-quinazolin-4-yl)-[3-(2-methyl-thiazol-4-yl)-phenyl]-amine;
(6,7-diethoxy-quinazolin-4-yl)-[3-(2-dimethylamino-thiazol-4-yl)-phenyl]-amine;
(6,7-diethoxy-quinazolin-4-yl)-[3-(2-ethoxy-thiazol-4-yl)-phenyl]-amine;
(6,7-diethoxy-quinazolin-4-yl)-[3-(2-methoxy-thiazol-4-yl)-phenyl]-amine;
4-[3-(6,7-diethoxy-quinazolin-4-ylamino)-phenyl]-thiazole-2-carboxylic acid amide;
(6,7-diethoxy-quinazolin-4-yl)-[3-(2-hydrazino-thiazol-4-yl)-phenyl]-amine;
(6,7-diethoxy-quinazolin-4-yl)-[3-(2-methoxymethyl-thiazol-4-yl)-phenyl]-amine;
(6,7-diethoxy-2-ethyl-quinazolin-4-yl)-[3-(2-methyl-thiazol-4-yl)-phenyl]-amine;
(6,7-diethoxy-2-methyl-quinazolin-4-yl)-[3-(2-methyl-thiazol-4-yl)-phenyl]-amine;
(6,7-diethoxy-2-isopropyl-quinazolin-4-yl)-[3-(2-methyl-thiazol-4-yl)-phenyl]-amine;
(6,7-diethoxy-quinazolin-4-yl)-[3-(2-methylamino-thiazol-4-yl)-phenyl]-amine;
[3-(2-cyclopropyl-thiazol-4-yl)-phenyl]-(6,7-diethoxy-quinazolin-4-yl)-amine;
(6,7-diethoxy-2-propyl-quinazolin-4-yl)-[3-(2-methyl-thiazol-4-yl)-phenyl]-amine;
(6,7-diethoxy-2-methoxymethyl-quinazolin-4-yl)-[3-(2-methyl-thiazol-4-yl)-phenyl]-amine;
(2-cyclopropyl-6,7-diethoxy-quinazolin-4-yl)-[3-(2-methyl-thiazol-4-yl)-phenyl]-amine;
(6,7-diethoxy-2-methylsulfanylmethyl-quinazolin-4-yl)-[3-(2-methyl-thiazol-4-yl)-phenyl]-amine;
(6,7-diethoxy-2-methanesulfonylmethyl-quinazolin-4-yl)-[3-(2-methyl-thiazol-4-yl)-phenyl]-amine;
(6,7-diethoxy-2-isobutyl-quinazolin-4-yl)-[3-(2-methyl-thiazol-4-yl)-phenyl]-amine;
(6-ethoxy-7-methoxy-quinazolin-4-yl)-[3-(2-methyl-thiazol-4-yl)-phenyl]-amine;
(7-ethoxy-6-methoxy-quinazolin-4-yl)-[3-(2-methyl-thiazol-4-yl)-phenyl]-amine;
[2-(2-chloro-ethyl)-6,7-diethoxy-quinazolin-4-yl]-[3-(2-methyl-thiazol-4-yl)-phenyl]-amine;
{6,7-diethoxy-4-[3-(2-methyl-thiazol-4-yl)-phenylamino]-quinazolin-2-yl}-acetic acid;
(2-chloromethyl-6,7-diethoxy-quinazolin-4-yl)-[3-(2-methyl-thiazol-4-yl)-phenyl]-amine;
{6,7-diethoxy-4-[3-(2-methyl-thiazol-4-yl)-phenylamino]-quinazolin-2-yl}-acetic acid ethyl ester;
(2-butyl-6,7-diethoxy-quinazolin-4-yl)-[3-(2-methyl-thiazol-4-yl)-phenyl]-amine;
{6,7-diethoxy-4-[3-(2-methyl-thiazol-4-yl)-phenylaminol-quinazolin-2-yl}-acetic acid methyl ester;
(2-diethylaminomethyl-6,7-diethoxy-quinazolin-4-yl)-[3-(2-methyl-thiazol-4-yl)-phenyl]-amine;
(6,7-diethoxy-2-ethylaminomethyl-quinazolin-4-yl)-[3-(2-methyl-thiazol-4-yl)-phenyl]-amine;
(2-dimethylaminomethyl-6,7-diethoxy-quinazolin-4-yl)-[3-(2-methyl-thiazol-4-yl)-phenyl]-amine;
(6,7-diethoxy-2-morpholin-4-ylmethyl-quinazolin-4-yl)-[3-(2-methyl-thiazol-4-yl)-phenyl]-amine;
(6,7-diethoxy-2-piperidin-1-ylmethyl-quinazolin-4-yl)-[3-(2-methyl-thiazol-4-yl)-phenyl]-amine;
(6,7-diethoxy-2-pyrrolidin-1-ylmethyl-quinazolin-4-yl)-[3-(2-methyl-thiazol-4-yl)-phenyl]-amine;
[6,7-diethoxy-2-(4-methyl-piperazin-1-ylmethyl)-quinazolin-4-yl]-[3-(2-methyl-thiazol-4-yl)-phenyl]-amine;
(6,7-diethoxy-2-methylaminomethyl-quinazolin-4-yl)-[3-(2-methyl-thiazol-4-yl)-phenyl]-amine;
{6,7-diethoxy-4-[3-(2-methyl-thiazol-4-yl)-phenylamino]-quinazolin-2-yl}-acetic acid;
(6,7-diethoxy-quinazolin-4-yl)-[4-fluoro-3-(2-methyl-thiazol-4-yl)-phenyl]-amine;
[4-chloro-3-(2-methyl-thiazol-4-yl)-phenyl]-(6,7-diethoxy-quinazolin-4-yl)-amine;
(6,7-diethoxy-quinazolin-4-yl)-[2-fluoro-5-(2-methyl-thiazol-4-yl)-phenyl]-amine;
[2-chloro-5-(2-methyl-thiazol-4-yl)-phenyl]-(6,7-diethoxy-quinazolin-4-yl)-amine;
(6,7-diethoxy-quinazolin-4-yl)-[2-methyl-5-(2-methyl-thiazol-4-yl)-phenyl]-amine;
(6,7-diethoxy-quinazolin-4-yl)-[2-methoxy-5-(2-methyl-thiazol-4-yl)-phenyl]-amine;
(6,7-diethoxy-quinazolin-4-yl)-(3-pyridin-3-yl-phenyl)-amine;
(2-aminomethyl-6,7-diethoxy-quinazolin-4-yl)-[3-(2-methyl-thiazol-4-yl)-phenyl]-amine;
(6,7-diethoxy-quinazolin-4-yl)-[3-(2,5-dimethyl-thiazol-4-yl)-phenyl]-amine;
[2-(2-amino-ethyl)-6,7-diethoxy-quinazolin-4-yl]-[3-(2-methyl-thiazol-4-yl)-phenyl]-amine;
[2-(3-chloro-propyl)-6,7-diethoxy-quinazolin-4-yl]-[3-(2-methyl-thiazol-4-yl)-phenyl]-amine;
(6,7-diethoxy-2-thiazolidin-3-ylmethyl-quinazolin-4-yl)-[3-(2-methyl-thiazol-4-yl)-phenyl]-amine;
(7-isopropoxy-6-methoxy-quinazolin-4-yl)-[3-(2-methyl-thiazol-4-yl)-phenyl]-amine;
4-[3-(6,7-diethoxy-2-thiazolidin-3-ylmethyl-quinazolin-4-ylamino)-phenyl]-thiazole-2-carboxylic acid amide;
4-[5-(6,7-diethoxy-2-thiazolidin-3-ylmethyl-quinazolin-4-ylamino)-2-fluoro-phenyl]-thiazole-2-carboxylic acid amide;
(6,7-diethoxy-2-piperazin-1-ylmethyl-quinazolin-4-yl)-[3-(2-methyl-thiazol-4-yl)-phenyl]-amine;
2-[3-(6,7-diethoxy-quinazolin-4-ylamino)-phenyl]-thiazole-4-carboxylic acid amide;
(6,7-diethoxy-quinazolin-4-yl)-[3-(4-methyl-thiazol-2-yl)-phenyl]-amine;
4-[5-(2-dimethylaminomethyl-6,7-diethoxy-quinazolin-4-ylamino)-2-fluoro-phenyl]-thiazole-2-carboxylic acid amide;
4-[3-(2-dimethylaminomethyl-6,7-diethoxy-quinazolin-4-ylamino)-phenyl]-thiazole-2-carboxylic acid amide;
(2-dimethylaminomethyl-6,7-diethoxy-quinazolin-4-yl)-[4-fluoro-3-(2-methyl-thiazol-4-yl)-phenyl]-amine;
4-[3-(6,7-diethoxy-2-morpholin-4-ylmethyl-quinazolin-4-ylamino)-phenyl]-thiazole-2-carboxylic acid amide;
4-[5-(6,7-diethoxy-2-morpholin-4-ylmethyl-quinazolin-4-ylamino)-2-fluoro-phenyl]-thiazole-2-carboxylic acid amide;
(6,7-diethoxy-2-morpholin-4-ylmethyl-quinazolin-4-yl)-[4-fluoro-3-(2-methyl-thiazol-4-yl)-phenyl]-amine;
(7-sec-butoxy-6-methoxy-quinazolin-4-yl)-[3-(2-methyl-thiazol-4-yl)-phenyl]-amine;
(6-methoxy-7-propoxy-quinazolin-4-yl)-[3-(2-methyl-thiazol-4-yl)-phenyl]-amine;
2-[3-(6,7-diethoxy-2-thiazolidin-3-ylmethyl-quinazolin-4-ylamino)-phenyl]-thiazole-4-carboxylic acid amide;
(6,7-diethoxy-2-thiazolidin-3-ylmethyl-quinazolin-4-yl)-[3-(4-methyl-thiazol-2-yl)-phenyl]-amine;
(6,7-diethoxy-2-thiazolidin-3-ylmethyl-quinazolin-4-yl)-[4-fluoro-3-(2-methyl-thiazol-4-yl)-phenyl]-amine;
(6,7-diethoxy-2-thiomorpholin-4-ylmethyl-quinazolin-4-yl)-[4-fluoro-3-(2-methyl-thiazol-4-yl)-phenyl]-amine;
4-[5-(6,7-diethoxy-2-thiomorpholin-4-ylmethyl-quinazolin-4-ylamino)-2-fluoro-phenyl]-thiazole-2-carboxylic acid amide;
4-[3-(6,7-diethoxy-2-thiomorpholin-4-ylmethyl-quinazolin-4-ylamino)-phenyl]-thiazole-2-carboxylic acid amide;
4-[3-(6,7-diethoxy-2-pyrazol-1-ylmethyl-quinazolin-4-ylamino)-phenyl]-thiazole-2-carboxylic acid amide;
(6,7-diethoxy-2-pyrazol-1-ylmethyl-quinazolin-4-yl)-[3-(2-methyl-thiazol-4-yl)-phenyl]-amine;
{4-[3-(6,7-diethoxy-quinazolin-4-ylamino)-phenyl]-thiazol-2-yl}-methanol;
(6,7-diethoxy-2-imidazol-1-ylmethyl-quinazolin-4-yl)-[3-(2-methyl-thiazol-4-yl)-phenyl]-amine;
(6,7-diethoxy-2-thiomorpholin-4-ylmethyl-quinazolin-4-yl)-[3-(2-methyl-thiazol-4-yl)-phenyl]-amine;
(6-ethoxy-7-propoxy-quinazolin-4-yl)-[3-(2-methyl-thiazol-4-yl)-phenyl]-amine;
(6-ethoxy-7-isopropoxy-quinazolin-4-yl)-[3-(2-methyl-thiazol-4-yl)-phenyl]-amine;
4-[3-(6,7-diethoxy-2-piperidin-1-ylmethyl-quinazolin-4-ylamino)-phenyl]-thiazole-2-carboxylic acid amide;
4-[5-(6,7-diethoxy-2-piperidin-1-ylmethyl-quinazolin-4-ylamino)-2-fluoro-phenyl]-thiazole-2-carboxylic acid amide;
(6,7-diethoxy-2-piperidin-1-ylmethyl-quinazolin-4-yl)-[4-fluoro-3-(2-methyl-thiazol-4-yl)-phenyl]-amine;
4-[3-(6,7-diethoxy-2-pyrrolidin-1-ylmethyl-quinazolin-4-ylamino)-phenyl]-thiazole-2-carboxylic acid amide;
4-[5-(6,7-diethoxy-2-imidazol-1-ylmethyl-quinazolin-4-ylamino)-2-fluoro-phenyl]-thiazole-2-carboxylic acid amide;
4-{5-[6,7-diethoxy-2-(4-methyl-piperazin-1-ylmethyl)-quinazolin-4-ylamino]-2-fluoro-phenyl}-thiazole-2-carboxylic acid amide;
(6,7-diethoxy-2-pyrrolidin-1-ylmethyl-quinazolin-4-yl)-[4-fluoro-3-(2-methyl-thiazol-4-yl)-phenyl]-amine;
4-[5-(6,7-diethoxy-2-pyrrolidin-1-ylmethyl-quinazolin-4-ylamino)-2-fluoro-phenyl]-thiazole-2-carboxylic acid amide;
(6,7-diethoxy-quinazolin-4-yl)-[2-ethoxy-5-(2-methyl-thiazol-4-yl)-phenyl]-amine;
(6,7-diethoxy-quinazolin-4-yl)-[2-ethyl-5-(2-methyl-thiazol-4-yl)-phenyl]-amine;
(6,7-diethoxy-quinazolin-4-yl)-(3-pyridin-2-yl-phenyl)-amine;
4-[3-(6-ethoxy-7-propoxy-quinazolin-4-ylamino)-phenyl]-thiazole-2-carboxylic acid amide;
4-[3-(6-ethoxy-7-isopropoxy-quinazolin-4-ylamino)-phenyl]-thiazole-2-carboxylic acid amide;
4-[3-(7-sec-butoxy-6-methoxy-quinazolin-4-ylamino)-phenyl]-thiazole-2-carboxylic acid amide;
(6-ethoxy-7-propoxy-quinazolin-4-yl)-[4-fluoro-3-(2-methyl-thiazol-4-yl)-phenyl]-amine;
(6-ethoxy-7-isopropoxy-quinazolin-4-yl)-[4-fluoro-3-(2-methyl-thiazol-4-yl)-phenyl]-amine;
4-[5-(7-sec-butoxy-6-methoxy-quinazolin-4-ylamino)-2-fluoro-phenyl]-thiazole-2-carboxylic acid amide;
4-[5-(6-ethoxy-7-isopropoxy-quinazolin-4-ylamino)-2-fluoro-phenyl]-thiazole-2-carboxylic acid amide;
{4-[3-(6-ethoxy-7-isopropoxy-quinazolin-4-ylamino)-phenyl]-thiazol-2-yl}-methanol;
2-[3-(6-ethoxy-7-isopropoxy-quinazolin-4-ylamino)-phenyl]-thiazole-4-carboxylic acid amide;
4-[3-(7-sec-butoxy-6-ethoxy-quinazolin-4-ylamino)-phenyl]-thiazole-2-carboxylic acid amide;
{4-[3-(7-sec-butoxy-6-ethoxy-quinazolin-4-ylamino)-phenyl]-thiazol-2-yl}-methanol;
2-[3-(7-sec-butoxy-6-ethoxy-quinazolin-4-ylamino)-phenyl]-thiazole-4-carboxylic acid amide;
{4-[3-(2-dimethylaminomethyl-6,7-diethoxy-quinazolin-4-ylamino)-phenyl]-thiazol-2-yl}-methanol;
[2-(2-dimethylamino-ethyl)-6,7-diethoxy-quinazolin-4-yl]-[3-(2-methyl-thiazol-4-yl)-phenyl]-amine;
4-[3-(6,7-diethoxy-2-methoxymethyl-quinazolin-4-ylamino)-phenyl]-thiazole-2-carboxylic acid amide;
{4-[3-(6,7-diethoxy-2-methoxymethyl-quinazolin-4-ylamino)-phenyl]-thiazol-2-yl}-methanol;
{4-[3-(6,7-diethoxy-2-morpholin-4-ylmethyl-quinazolin-4-ylamino)-phenyl]-thiazol-2-yl}-methanol;
2-[3-(6,7-diethoxy-2-morpholin-4-ylmethyl-quinazolin-4-ylamino)-phenyl]-thiazole-5-carboxylic acid amide;
(4-{3-[6,7-diethoxy-2-(4-methyl-piperazin-1-ylmethyl)-quinazolin-4-ylamino]-phenyl}-thiazol-2-yl)-methanol;
2-{3-[6,7-diethoxy-2-(4-methyl-piperazin-1-ylmethyl)-quinazolin-4-ylamino]-phenyl}-thiazole-5-carboxylic acid amide;
2-[3-(6,7-diethoxy-2-imidazol-1-ylmethyl-quinazolin-4-ylamino)-phenyl]-thiazole-4-carboxylic acid amide;
{4-[3-(6,7-diethoxy-2-imidazol-1-ylmethyl-quinazolin-4-ylamino)-phenyl]-thiazol-2-yl}-methanol;
(6,7-diethoxy-2-methoxymethyl-quinazolin-4-yl)-(3-pyridin-2-yi-phenyl)-amine;
(6,7-diethoxy-quinazolin-4-yl)-(3-quinolin-3-yl-phenyl)-amine;
[6,7-diethoxy-2-(2-morpholin-4-yl-ethyl)-quinazolin-4-yl]-[3-(2-methyl-thiazol-4-yl)-phenyl]-amine;
4-{3-[6,7-diethoxy-2-(2-morpholin-4-yl-ethyl)-quinazolin-4-ylamino]-phenyl}-thiazole-2-carboxylic acid amide;
(6,7-diethoxy-quinazolin-4-yl)-[3-(2-methyl-oxazol-4-yl)-phenyl]-amine;
4-[3-(6,7-diethoxy-2-imidazol-1-ylmethyl-quinazolin-4-ylamino)-phenyl]-thiazole-2-carboxylic acid amide;
(6,7-diethoxy-quinazolin-4-yl)-(3-pyrimidin-4-yl-phenyl)-amine;
4-[3-(6-ethoxy-7-isopropoxy-2-methoxymethyl-quinazolin-4-ylamino)-phenyl]-thiazole-2-carboxylic acid amide;
{4-[3-(6-ethoxy-7-isopropoxy-2-methoxymethyl-quinazolin-4-ylamino)-phenyl]-thiazol-2-yl}-methanol;
(2-chloromethyl-6-ethoxy-7-isopropoxy-quinazolin-4-yl)-[3-(2-methyl-thiazol-4-yl)-phenyl]-amine;
(6-ethoxy-7-isopropoxy-2-morpholin-4-ylmethyl-quinazolin-4-yl)-[3-(2-methyl-thiazol-4-yl)-phenyl]-amine;
{4-[3-(6-ethoxy-7-isopropoxy-2-morpholin-4-ylmethyl-quinazolin-4-ylamino)-phenyl]-thiazol-2-yl}-methanol;
2-[3-(6-ethoxy-7-isopropoxy-2-morpholin-4-ylmethyl-quinazolin-4-ylamino)-phenyl]-thiazole-4-carboxylic acid amide;
2-[3-(6,7-diethoxy-quinazolin-4-ylamino)-phenyl]-thiazole-4-carbonitrile;
(6-ethoxy-7-isopropoxy-quinazolin-4-yl)-(3-thiazol-5-yl-phenyl)-amine;
2-[3-(6-ethoxy-7-isopropoxy-quinazolin-4-ylamino)-phenyl]-thiazole-4-carbonitrile;
(6-ethoxy-2-imidazol-1-ylmethyl-7-isopropoxy-quinazolin-4-yl)-[3-(2-methyl-thiazol-4-yl)-phenyl]-amine;
4-[3-(6-ethoxy-2-imidazol-1-ylmethyl-7-isopropoxy-quinazolin-4-ylamino)-phenyl]-thiazole-2-carboxylic acid amide;
{4-[3-(6-ethoxy-2-imidazol-1-ylmethyl-7-isopropoxy-quinazolin-4-ylamino)-phenyl]-thiazol-2-yl}-methanol;
2-[3-(6-ethoxy-2-imidazol-1-ylmethyl-7-isopropoxy-quinazolin-4-ylamino)-phenyl]-thiazole-4-carboxylic acid amide;
4-[3-(2-dimethylaminomethyl-6-ethoxy-7-isopropoxy-quinazolin-4-ylamino)-phenyl]-thiazole-2-carboxylic acid amide;
{4-[3-(2-dimethylaminomethyl-6-ethoxy-7-isopropoxy-quinazolin-4-ylamino)-phenyl]-thiazol-2-yl}-methanol;
and {4-[3-(2-chloromethyl-6-ethoxy-7-isopropoxy-quinazolin-4-ylamino)-phenyl]-thiazol-2-yl}-methanol.

142 more elements

Dependencies are inferred from the claim text.

Facts

Application: 10/251,073Filed 20 Sep 2002
Priority: 24 Sep 2001
Published: 31 Jul 2003
Term ends: Not estimatedThe source records don’t support an estimate.

Classification7 codes

C07D 401/12
Containing two hetero rings: linked by a chain containing hetero atoms as chain links
C07D 403/12
Containing two hetero rings: linked by a chain containing hetero atoms as chain links
C07D 405/12
Containing two hetero rings: linked by a chain containing hetero atoms as chain links
C07D 413/12
Containing two hetero rings: linked by a chain containing hetero atoms as chain links

Family

Application60/324,751Us provisional application · filed 24 Sep 2001
US 2003/0144308 A1This patent

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Abstract

Facts

Application

10/251,073Filed 20 Sep 2002

Priority

24 Sep 2001

Published

31 Jul 2003

Term ends

Not estimatedThe source records don’t support an estimate.

Classification7 codes

C07D 401/12
Containing two hetero rings: linked by a chain containing hetero atoms as chain links
C07D 403/12
Containing two hetero rings: linked by a chain containing hetero atoms as chain links
C07D 405/12
Containing two hetero rings: linked by a chain containing hetero atoms as chain links
C07D 413/12
Containing two hetero rings: linked by a chain containing hetero atoms as chain links