Therapeutic combinations of antihypertensive and antiangiogenics agents
AssigneeAstraZeneca AB
InventorsJon Owen Curwen, Donald James Ogilvie
Life of this patent
Estimating the term…
Abstract
The invention concerns the use of a combination of an anti-angiogenic agent and an anti-hypertensive agent for use in the manufacture of a medicament for the treatment of a disease state associated with angiogenesis in a warm-blooded mammal, such as a human being. The invention also relates to pharmaceutical compositions comprising an anti-angiogenic agent and an anti-hypertensive agent, to kits thereof and to a method of treatment of a disease state associated with angiogenesis which comprises the administration of an effective amount of a combination of an anti-angiogenic agent and an anti-hypertensive agent to a warm-blooded animal, such as a human being.
Claims14
Use of a combination of an anti-angiogenic agent and an anti-hypertensive agent for use in the manufacture of a medicament for the treatment of a disease state associated with angiogenesis in a warm-blooded mammal, such as a human being.
Use according to any one of the preceding claims wherein the anti-hypertensive agent is a calcium channel blocker, an A-II antagonists an ACE inhibitor or a β-blocker.
Use according to any one of the preceding claims wherein the anti-hypertensive agent is an ACE inhibitor.
A pharmaceutical composition, comprising:
- a) an anti-angiogenic agent or a pharmaceutically acceptable salt, solvate or pro-drug thereof;
- b) an anti-hypertensive agent or a pharmaceutically acceptable salt, solvate or pro-drug thereof;
- and optionally
- c) a pharmaceutically acceptable carrier or diluent.
A kit, for use in producing an anti-angiogenic effect and/or vascular permeability reducing effect in a warm-blooded animal such as a human being, comprising:
- a) an anti-angiogenic agent or a pharmaceutically acceptable salt, solvate or pro-drug thereof or a pharmaceutical composition thereof;
- b) an anti-hypertensive or a pharmaceutically acceptable salt, solvate or pro-drug thereof or a pharmaceutical composition thereof;
- and
- c) a container means for containing said agents.
A method of treatment of a disease state associated with angiogenesis which comprises the administration of an effective amount of a combination of an anti-angiogenic agent and an anti-hypertensive agent to a warm-blooded animal, such as a human being.
Dependencies are inferred from the claim text.