Quinoline and quinoxaline compounds which inhibit platelet-derived growth factor and/or p56lck tyrosine kinases

A compound of formula I

• 9
• wherein
• R1a is optionally substituted alkyl, hydroxy, acyloxy, optionally substituted alkoxy, optionally substituted cycloalkyloxy, optionally substituted oxabeterocyclyloxy, optionally substituted heterocyclylcarbonyloxy or halo;
• R1b is hydrogen, optionally substituted alkyl, hydroxy, acyloxy, optionally substituted alkoxy, optionally substituted cycloalkyloxy, optionally substituted oxaheterocyclyloxy, optionally substituted heterocyclylcarbonyloxy or halo;
• R1c is hydrogen, optionally substituted alkyl, optionally substituted aryl. optionally substituted heteroaryl, hydroxy, acyloxy, optionally substituted alkoxy, optionally substituted cycloalkyloxy, optionally substituted heterocyclyloxy, optionally substituted aryloxy, optionally substituted heteroaryloxy, optionally substituted heterocyclylcarbonyloxy, halo, cyano. R5R6N- or acylR5N—;
• 10
• R3 is hydrogen, or ortho or para fluoro, or meta lower alkyl, lower alkoxy, halo or carbamoyl;
• R4 is hydrogen or lower alkyl;
• R5 and R6 are independently hydrogen or alkyl, or R5 and R6 taken together with the nitrogen atom to which R5 and R6 are attached form azaheterocyclyl;
• Za is N or CH;
• and
• Zb is NH or O, or
• an N-oxide thereof, hydrate thereof, solvate thereof, prodrug thereof, or salt thereof, provided that R1a and R1b are not both optionally substituted alkyl.