5-Heterocyclo-pyrazoles

A compound of formula I:

• 14
• or a pharmaceutically acceptable salt thereof;
• wherein m is 0, 1 or 3;
• n is 1, 2, or 3;
• wherein ring W is connected to the pyrazole ring through a nitrogen atom and is a radical selected from the group consisting of:
• a) a saturated, partially saturated or aromatic (3- to 7-membered)-heterocyclyl ring optionally containing one to four ring heteroatoms independently selected from the groups consisting of —N═, —NH—, —O—, and —S—;
• b) a saturated, partially saturated or aromatic (3- to 7-membered)-heterocyclyl ring optionally containing one to four ring heteroatoms independently selected from the groups consisting of —N═, —NH—, —O—, and —S—;
• wherein said saturated, partially saturated or aromatic (3- to 7-membered)-heterocyclyl is fused to a a saturated, partially saturated or aromatic (3- to 7-membered)-carbocyclic ring;
• and
• c) a saturated, partially saturated or aromatic (3- to 7-membered)-heterocyclyl ring optionally containing one to four ring heteroatoms independently selected from the groups consisting of —N═, —NH—, —O—, and —S—;
• wherein said saturated, partially saturated or aromatic (3- to 7-membered)-heterocyclyl is fused to a saturated, partially saturated or aromatic (3- to 7-membered)-heterocyclyl containing one to two ring heteroatoms independently selected from the group consisting of —N═, —NH—, —S— and —O—;
• R1 is a radical selected from the group consisting of H, —NO2, —CN, (C1-C6)alkyl, (C1-C6)alkyl-SO2—, (C6-C10)aryl-SO2—, H—(C═O)—, (C1-C6)alkyl-(C═O)—, (C1-C6)alkyl-O—(C═O)—, (C1-C9)heteroaryl-(C═O)—, (C1-C9)heterocyclyl-(C═O)—, H2N—(C═O)—, (C1-C6)alkyl-NH—(C═O)—, [(C1-C6)alkyl]2—N—(C═O)—, [(C6-C10)aryl]-NH—(C═O)—, f(C1-C6)alkyl]-[((C6-C10)aryl)-N]—(C═O)—, HO—NH—(C═O)—, and (C1-C6)alkyl-O—NH—(C═O)—;
• R2 is a radical selected from the group consisting of H, —NO2, —CN, (C2-C6)alkenyl, (C2-C6)alkynyl, (C3-C7)cycloalkyl, (C6-C10)aryl, (C1-C9)heteroaryl, (C1-C9)heterocyclyl, (CG-C6)alkyl-O—, (C3-C7)cycloalkyl-O—, (C6-C10)aryl-O—, (C1-C9)heteroaryl-O—, (C1-C9)heterocyclyl-O—, H—(C═O)—, (C1-C6)alkyl-(C═O)—, (C3-C7)cycloalkyl-(C═O)—, (C6-C10)aryl-(C═O)—, (C1-C9)heteroaryl-(C═O)—, (C1-C9)heterocyclyl-(C═O)—, (C1-C6)alkyl-O—(C═O)—, (C3-C7)cycloalkyl-O—(C═O)—, (C6-C10)aryl-O—(C═O)—, (C1-C9)heteroaryl-O—(C═O)—, (C1-C9)heterocyclyl-O—(C═O)—, (C1-C6)alkyl-(C═O)—O—, (C3-C7)cycloalkyl-(C═O)—O—, (C6-C10)aryl-(C═O)—O—, (C1-C9)heteroaryl-(C═O)—O—, (C1-C9)heterocyclyl-(C═O)—O—, (C1-C6)alkyl-(C═O)—NH—, (C3-C7)cycloalkyl-(C═O)—NH—, (C6-C10)aryl-(C═O)—NH—, (C1-C9)heteroaryl-(C═O)—NH—, (C1-C9)heterocyclyl-(C═O)—NH—, (C1-C6)alkyl-O—(C═O)—NH—, (C1-C6)alkyl-NH, [(C1-C6)alkyl]2—N—, (C3-C7)cycloalkyl-NH—, [(C3-C7)cycloalkyl]2—N—, [(C6-C10)aryl]-NH—, [(C6-C10)aryl]2—N—, [(C1-C6)alkyl]-[((C6-C10)aryl)-N]—, [(C1-C9)heteroaryl]-NH—, [(C1-C9)heteroaryl]2—N—, [(C1-C9)heterocyclyl]-NH—, [(C1-C9)heterocyclyl]2—N—, H2N—(C═O)—, HO—NH—(C═O)—, (C1-C6)alkyl-O—NH—(C═O)—, [(C1-C6)alkyl]-NH—(C═O)—, [(C1-C6)alkyl]2—N—(C═O)—, [(C3-C7)cycloalkyl]-NH—(C═O)—, [(C3-C7)cycloalkyl]2—N—(C═O)—, [(C6-C10)aryl]-NH—(C═O)—, [(C6-C10)aryl]2—N—(C═O)—, [(C1-C6)alkyl]-[((C6-C10)aryl)-N]—(C═O)—, [(C1-C9)heteroaryl]-NH—(C═O)—, [(C1-C9)heteroaryl]2—N—(C═O)—, [(C1-C9)heterocyclyl]-NH—(C═O)—, (C1-C6)alkyl-S— and (C1-C6)alkyl optionally substituted by one —OH group or by one to four fluoro substituents;
• Each R3 is a radical independently selected from the group consisting of H, halo, —OH, —CN, —NO2, (C2-C6)alkenyl, (C2-C6)alkynyl, (C3-C7)cycloalkyl, (C6-C10)aryl, (C2-C9)heterocyclyl, (C1-C6)alkyl-O—, H—(C═O)—, (C1-C6)alkyl-(C═O)—, HO—(C═O)—, (C1-C6)alkyl-O—(C═O)—, —NH2, (C1-C6)alkyl-NH—, [(C1-C6)alkyl]2—N—, (C3-C7)cycloalkyl-NH—, (C6-C10)aryl-NH—, [(C1-C6)alkyl]-[((C6-C10)aryl)-N]—, (C1-C9)heteroaryl-NH—, H2N—(C═O)—, [(C1-C6)alkyl]-NH—(C═O)—, [(C1-C6)alkyl]2—N—(C═O)—, [(C6-C10)aryl]-NH—(C═O)—, [(C1-C6)alkyl]-[((C6-C10)aryl)-N]—(C═O)—, (C1-C6)alkyl-O—NH—(C═O)—, (C1-C6)alkyl-(C═O)—HN—, (C1-C6)alkyl-(C═O)—[(C1-C6)alkyl-N]—, —SH, (C1-C6)alkyl-S—, (C1-C6)alkyl-(S═O)—, (C1-C6)alkyl-SO2—, and (C1-C6)alkyl optionally substituted with one to four fluoro substituents;
• R4 is an (C1-C6)alkyl radical, wherein said (C1-C6)alkyl radical may optionally be substituted by one to four fluoro substituents;
• R5 is a radical selected from the group consisting of H, halo, —OH, (C1-C6)alkyl-O—, (C2-C6)alkenyl, (C2-C6)alkynyl, (C3-C7)cycloalkyl, —CN, H—(C═O)—, (C1-C6)alkyl-(C═O)—, (C1-C6)alkyl-(C═O)—O—, HO—(C═O)—, (C1-C6)alkyl-O—(C═O)—, (C1-C6)alkyl-NH—, [(C1-C6)alkyl]2—N—, (C3-C7)cycloalkyl-NH—, (C6-C10)aryl-NH—, [(C1-C6)alkyl]-[((C6-C10)aryl)-N]—, (C1-C9)heteroaryl-NH—, H2N—(C═O)—, (C1-C6)alkyl-NH—(C═O)—, [(C1-C6)alkyl]2—N—(C═O)—, (C6-C10)aryl-(C═O)—, [(C1-C6)alkyl]-[((C6-C10)aryl)-N]—(C═O)—, (C1-C6)alkyl-O—NH—(C═O)—, (C1-C6)alkyl-S—, and (C1-C6)alkyl optionally substituted with one to four fluoro substituents.