Heterocycle-containing carboxylic acid derivative and drug containing the same

A heterocycle—containing carboxylic acid derivative represented by the following formula (I)

• 246
• wherein A is a group represented by the following formula (i), (ii), (iii) or (iv):
• 247
• in which E1, F1, G1, H1, I1, E2, F2, G2, E3, F3 and G3 are the same or different and each independently represents an oxygen atom or a nitrogen, carbon or sulfur atom which may have a substituent;
• J represents a nitrogen atom which may have a substituent, with the proviso that the cases where in the ring (i), E1, F1, G1, H1 and I1 each represents a carbon group which may have a substituent, where in the ring (ii), E2, F2 and G2 each represents a carbon group which may have a substituent, and where in the ring (iii), E3, F3 and G2 each represents a carbon group which may have a substituent are excluded;
• R1, R2 and R3 are the same or different and each independently represents a hydrogen atom, a halogen atom, a lower alkyl group which may have a substituent, a cycloalkyl group which may have a substituent, a lower alkoxy group which may have a substituent, a cycloalkyloxy group which may have a substituent, an aryl group which may have a substituent, a heteroaryl group which may have a substituent, an aryloxy group which may have a substituent, a heteroaryloxy group which may have a substituent, a cycloalkylalkyl group which may have a substituent, an arylalkyl group which may have a substituent, a heteroarylalkyl group which may have a substituent, a cycloalkylalkyloxy group which may have a substituent, an arylalkyloxy group which may have a substituent, a heteroarylalkyloxy group which may have a substituent, an alkenyl group which may have a substituent or an alkynyl group which may have a substituent, or R1 and R2 are coupled together to form a cycloalkylene group which may have a substituent, a carbon group forming said cycloalkylene group may be substituted by a sulfur atom, an oxygen atom, a sulfinyl group, a sulfonyl group or >NR4, R4 representing a hydrogen atom or a lower alkyl group, and n2 stands for 1 to 3;
• B is a heteroarylene group which may have a substituent, an arylene group which may have a substituent, or a group represented by the following formula:
• 248
• wherein R5 represents a hydrogen atom or a lower alkyl group;
• R6 and R7 are the same or different and each independently represents a hydrogen atom, a lower alkyl group or a halogen atom and m1 stands for 1 to 3, m2 stands for 0 to 2;
• R8 to R15 are the same or different and each independently represents a hydrogen atom or a lower alkyl group;
• X represents an oxygen atom, a sulfur atom or >NR4, R4 having the same meaning as defined above;
• D is an arylene group which may have a substituent, a heteroarylene group which may have a substituent, or a group represented by the formula:
• —CR6═CR7—, R6 and R7 having the same meanings as defined above;
• n1 stands for 0 or 1;
• M is a hydroxyl group, a lower alkoxy group or a group represented by the following formula:
• —NR16R17 in which R16 and R17 are the same or different and each independently represents a hydrogen atom, a hydroxyl group, a lower alkyl group, a lower alkoxy group, a hydroxyalkyl group, an aryl group or a heteroaryl group or R16 and R17 are coupled together with the adjacent nitrogen atom to form an oxygen- or sulfur-containing ring;
• and
• represents a single bond or double bond;
• or a physiologically acceptable salt thereof.