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US 2003/0144256 A1Published application
Male anti-fertility agents
AssigneeAllergan Sales, Inc.
InventorsElliott S. Klein, Yang-Dar Yuan, Roshantha A. Chandraratna
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Abstract
Methods and compositions for inhibiting or preventing spermatogenesis in a male mammal. Also disclosed are compounds and formulations for use in such methods.
Claims42
A method for inhibiting the ability of a male mammal to conceive progeny, comprising:
- regularly administering to said male mammal an effective amount of an RAR antagonist or inverse agonist for a period of time effective to sufficiently reduce or eliminate spermatozoa in the semen of said male mammal.
A method for inhibiting spermatogenesis in a male mammal, comprising:
- administering to said male mammal an effective amount of a composition comprising an RAR antagonist or inverse agonist over a period of time effective to prevent conception.
A contraceptive effective to inhibit spermatogenesis in a male mammal comprising:
- a) an RAR antagonist or inverse agonist, and
- b) a pharmaceutically acceptable excipient.
Dependencies are inferred from the claim text.