Acyclic and cyclic amine derivatives

A compound having formula (I):

• 145
• and pharmaceutically acceptable derivatives thereof, wherein:
• X is selected from —CH2CH2—, —CH═CH—, —C(OH)CH2—, —CH2C(OH)—, ═C(F)CH2—, —C(F)═CH2—, —NHC(O)—, —P(O)(OH)CH2—, —CH2SO2—, —C(S)NR1—, —C(O)CH2CH(OH)—, —C(OH)CF2—, —C(O)CF2—, —CH(F)CH2—, —C(F)2CH2—,
• 146
• A, B and R1 are independently E, (C1-C10)-straight or branched alkyl, (C2-C10)-straight or branched alkenyl or alkynyl, or (C5-C7)-cycloalkyl or cycloalkenyl;
• wherein 1 or 2 hydrogen atoms in said alkyl, alkenyl or alkynyl are optionally and independently replaced with E, (C5-C7)-cycloalkyl or cycloalkenyl;
• and wherein 1 to 2 of the —CH2— groups in said alkyl, alkenyl, or alkynyl groups is optionally and independently replaced by —O—, —S—, —S(O)—, —S(O)2—, ═N—, —N═ or —N(R3)—;
• or, B and R1 are independently hydrogen;
• R3 is hydrogen, (C1-C4)-straight or branched alkyl, (C3-C4)-straight or branched alkenyl or alkynyl, or (C1-C4) bridging alkyl, wherein a bridge is formed between the nitrogen atom to which said R3 is bound and any carbon atom of said alkyl, alkenyl or alkynyl to form a ring, and wherein said ring is optionally benzofused;
• E is a saturated, partially saturated or unsaturated, or aromatic monocyclic or bicyclic ring system, wherein each ring comprises 5 to 7 ring atoms independently selected from C, N, N(R3), O, S, S(O), or S(O)2;
• and wherein no more than 4 ring atoms are selected from N, N(R3), O, S, S(O), or S(O)2;
• wherein 1 to 4 hydrogen atoms in E are optionally and independently replaced with halogen, hydroxyl, hydroxymethyl, nitro, SO3H, trifluoromethyl, trifluoromethoxy, (C1-C6)-straight or branched alkyl, (C2-C6)-straight or branched alkenyl, O—[(C1-C6)-straight or branched alkyl], O—[(C3-C6)-straight or branched alkenyl], (CH2)n—N(R4)(R5), (CH2)n—NH(R4)—(CH2)n—Z, (CH2)n—N (R4—(CH2)n—Z)(R5—(CH2)n—Z), (CH2)n—Z, O—(CH2)n—Z, (CH2)n—O—Z, S—(CH2)n—Z, CH═CH—Z, 1,2-methylenedioxy, C(O)OH, C(O)O—[(C1-C6)-straight or branched alkyl], C(O)O—(CH2)n—Z or C(O)—N (R4)(R5);
• each of R4 and R5 are independently hydrogen, (C1-C6)-straight or branched alkyl, (C3-C5)-straight or branched alkenyl, or wherein R4 and R5, when bound to the same nitrogen atom, are taken together with the nitrogen atom to form a 5 or 6 membered ring, wherein said ring optionally contains 1 to 3 additional heteroatoms independently selected from N, N(R3), O, S, S(O), or S(O)2;
• wherein said alkyl, alkenyl or alkynyl groups in R4 and R5 are optionally substituted with Z.
• each n is independently 0 to 4;
• each Z is independently selected from a saturated, partially saturated or unsaturated, monocyclic or bicyclic ring system, wherein each ring comprises 5 to 7 ring atoms independently selected from C, N, N(R3), O, S, S(O), or S(O)2;
• and wherein no more than 4 ring atoms are selected from N, N(R3), O, S, S(O), or S(O)2;
• wherein 1 to 4 hydrogen atoms in Z are optionally and independently replaced with halo, hydroxy, nitro, cyano, C(O)OH, (C1-C3)-straight or branched alkyl, O—(C1-C3)-straight or branched alkyl, C(O)O—[(C1-C3)-straight or branched alkyl], amino, NH[(C1-C3)-straight or branched alkyl], or N—[(C1-C3)-straight or branched alkyl]2;
• J is H, methyl, ethyl or benzyl;
• K and K1 are independently selected from (C1-C6)-straight or branched alkyl, (C2-C6)-straight or branched alkenyl or alkynyl, or cyclohexylmethyl, wherein 1 to 2 hydrogen atoms in said alkyl, alkenyl or alkynyl is optionally and independently replaced with E;
• wherein K and K1 are independently and optionally substituted with up to 3 substituents selected from halogen, OH, O—(C1-C6)-alkyl, O—(CH2)n-Z, NO2, C(O)OH, C(O)—O—(C1-C6)-alkyl, C(O)NR4R5, NR4R5 and (CH2)n—Z;
• or,
• J and K, taken together with the nitrogen and carbon atom to which they are respectively bound, form a 5-7 membered heterocyclic ring, optionally containing up to 3 additional heteroatoms selected from N, N(R3), O, S, S(O), or S(O)2, wherein 1 to 4 hydrogen atoms in said heterocyclic ring are optionally and independently replaced with (C1-C6)-straight or branched alkyl, (C2-C6)-straight or branched alkenyl or alkynyl, oxo, hydroxyl or Z;
• and wherein any —CH2— group in said alkyl, alkenyl or alkynyl substituent is optionally and independently replaced by —O—, —S—, —S(O)—, —S(O2)—, ═N—, —N═, or —N(R3)—;
• and wherein said heterocyclic ring is optionally fused with E;
• G, when present, is —S(O)2—, —C(O)—, —S(O)2—Y—, —C(O)—Y—, —C(O)—C(O)—, or —C(O)—C(O)—Y—;
• Y is oxygen, or N(R6);
• wherein R6 is hydrogen, E, (C1-C6)-straight or branched alkyl, (C3-C6)-straight or branched alkenyl or alkynyl;
• or wherein R6 and D are taken together with the atoms to which they are bound to form a 5 to 7 membered ring system wherein said ring optionally contains 1 to 3 additional heteroatoms independently selected from O, S, N, N(R3), SO, or SO2;
• and wherein said ring is optionally benzofused;
• D is hydrogen, (C1-C7)-straight or branched alkyl, (C2-C7)-straight or branched alkenyl or alkynyl, (C5-C7)-cycloalkyl or cycloalkenyl optionally substituted with (C1-C6)-straight or branched alkyl or (C2-C7)-straight or branched alkenyl or alkynyl, [(C1-C7)-alkyl]-E, [(C2-C7)-alkenyl or alkynyl]-E, or E;
• wherein 1 to 2 of the CH2 groups of said alkyl, alkenyl or alkynyl chains in D is optionally replaced by —O—, —S—, —S(O)—, —S(O2)—, ═N—, —N═, or —N(R3);
• provided that when J is hydrogen or G is selected from —S(O)2—, C(O)C(O)—, SO2—Y, C(O)—Y, or C(O)C(O)—Y, wherein Y is O;
• then D is not hydrogen;
• and
• x is 0 or 1.