Combination product comprising a non-steroidal antiandrogen and an egfr tyrosine kinase inhibitor
OwnerBarrington John Albert Furrinventor
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Abstract
The invention concerns a combination therapeutic product comprising a non-steroidal antiandrogen and an epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) for use simultaneously, sequentially or separately in the synergistic treatment or prophylaxis of prostate cancer. In particular, the product of the invention is effective in inhibiting the transformation of prostate cancer cells from a hormone-dependent state into a hormone-independent state. It is further expected that the product of the invention will have a beneficial effect in preventing the onset of prostate cancer in men genetically predisposed to the disease.
Claims23
A combination therapeutic product comprising a non-steroidal antiandrogen and an epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) for use simultaneously, sequentially or separately in the synergistic treatment or prophylaxis of prostate cancer.
A pharmaceutical composition for use in the synergistic treatment or prophylaxis of prostate cancer which comprises a non-steroidal antiandrogen and an EGFR TKI in conjunction or admixture with pharmaceutically-acceptable diluents or carriers.
A combination therapeutic product comprising a non-steroidal antiandrogen, a chemical castration agent and an EGFR TKI for use simultaneously, sequentially or separately in the synergistic treatment or prophylaxis of prostate cancer.
A combination therapeutic product comprising an antiandrogen and an EGFR TKI for use simultaneously, sequentially or separately in reducing the transformation of prostatic cells to a malignant state in a human in need of such treatment.
A pharmaceutical composition for use in reducing the transformation of prostatic cells to a malignant state in a human in need of such treatment which comprises a non-steroidal antiandrogen and an EGFR TKI in conjunction or admixture with pharmaceutically-acceptable diluents or carriers.
Dependencies are inferred from the claim text.